Mascola, JR and Snyder, SW and Weislow, OS and Belay, SM and Belshe, RB and Schwartz, DH and Clements, ML and Dolin, R and Graham, BS and Gorse, GJ and Keefer, MC and McElrath, MJ and Walker, MC and Wagner, KF and McNeil, JG and McCutchan, FE and Burke, DS
(1996)
Immunization with envelope subunit vaccine products elicits neutralizing antibodies against laboratory-adapted but not primary isolates of human immunodeficiency virus type 1.
Journal of Infectious Diseases, 173 (2).
340 - 348.
ISSN 0022-1899
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Abstract
Phase I studies of volunteers not infected with human immunodeficiency virus type 1 (HIV-1) have shown that immunization with envelope subunit vaccine products elicits antibodies that neutralize laboratory-adapted (prototype) HIV-1 strains in vitro. Prototype strains are adapted to grow in continuous (neoplastic) cell lines and are more susceptible to neutralization than are primary isolates cultured in human peripheral blood mononuclear cells. In this study, 50 sera from nine phase I vaccine trials and 16 from HIV-1-infected persons were evaluated for neutralizing antibody activity against 3 laboratory-adapted and 5 primary HIV-1 isolates. Of 50 sera, 49 neutralized at least 1 of the prototype strains: however, none displayed neutralizing activity against primary isolates of HIV-1. Serum from most HIV- 1-infected persons neutralized both laboratory-adapted and primary HIV-1 isolates. These data demonstrate a qualitative, or large quantitative, difference in the neutralizing antibody response induced by envelope subunit vaccination and natural HIV-1 infection.
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Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID  |
---|
Mascola, JR | | | | Snyder, SW | | | | Weislow, OS | | | | Belay, SM | | | | Belshe, RB | | | | Schwartz, DH | | | | Clements, ML | | | | Dolin, R | | | | Graham, BS | | | | Gorse, GJ | | | | Keefer, MC | | | | McElrath, MJ | | | | Walker, MC | | | | Wagner, KF | | | | McNeil, JG | | | | McCutchan, FE | | | | Burke, DS | donburke@pitt.edu | DONBURKE | |
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Centers: |
Other Centers, Institutes, Offices, or Units > Center for Vaccine Research |
Date: |
1 January 1996 |
Date Type: |
Publication |
Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
Journal or Publication Title: |
Journal of Infectious Diseases |
Volume: |
173 |
Number: |
2 |
Page Range: |
340 - 348 |
DOI or Unique Handle: |
10.1093/infdis/173.2.340 |
Institution: |
University of Pittsburgh |
Schools and Programs: |
School of Public Health > Epidemiology |
Refereed: |
Yes |
ISSN: |
0022-1899 |
Date Deposited: |
05 May 2015 16:52 |
Last Modified: |
19 Jan 2019 15:55 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/24310 |
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