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Serotype-specific dengue virus circulation and dengue disease in Bangkok, Thailand from 1973 to 1999

Nisalak, A and Endy, TP and Nimmannitya, S and Kalayanarooj, S and Thisayakorn, U and Scott, RM and Burke, DS and Hoke, CH and Innis, BL and Vaughn, DW (2003) Serotype-specific dengue virus circulation and dengue disease in Bangkok, Thailand from 1973 to 1999. American Journal of Tropical Medicine and Hygiene, 68 (2). 191 - 202. ISSN 0002-9637

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Dengue virus circulation and association with epidemics and severe dengue disease were studied in hospitalized children with suspected dengue at the Queen Sirikit National Institute of Child Health in Bangkok, Thailand, from 1973 to 1999. Dengue serology was performed on all patients and viral isolation attempted on laboratory-confirmed patients. Acute dengue was diagnosed in 15, 569 children and virus isolated from 4,846. DEN-3 was the most frequent serotype in primary dengue (49% of all isolates), DEN-2 in secondary and in dengue hemorrhagic fever (37% and 35%, respectively). The predominant dengue serotype varied by year: DEN-1 from 1990-92, DEN-2 from 1973-86 and 1988-89; DEN-3 in 1987 and 1995-99; and DEN-4 from 1993-94. Only DEN-3 was associated with severe outbreak years. Our findings illustrate the uniqueness of each serotype in producing epidemics and severe disease and underscore the importance of long-term surveillance of dengue serotypes in understanding the epidemiology of these viruses.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Nisalak, A
Endy, TP
Nimmannitya, S
Kalayanarooj, S
Thisayakorn, U
Scott, RM
Burke, DSdonburke@pitt.eduDONBURKE
Hoke, CH
Innis, BL
Vaughn, DW
Centers: Other Centers, Institutes, Offices, or Units > Center for Vaccine Research
Date: 1 January 2003
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: American Journal of Tropical Medicine and Hygiene
Volume: 68
Number: 2
Page Range: 191 - 202
DOI or Unique Handle: 10.4269/ajtmh.2003.68.191
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0002-9637
Date Deposited: 08 May 2015 15:09
Last Modified: 21 Jun 2020 03:55


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