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Recombination in HIV: an important viral evolutionary strategy.

Burke, DS (1997) Recombination in HIV: an important viral evolutionary strategy. Emerg Infect Dis, 3 (3). 253 - 259. ISSN 1080-6040

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Abstract

Human immunodeficiency virus (HIV) is a diploid virus: each virion carries two complete RNA genomic strands. Homologous recombination can occur when a cell is coinfected with two different but related strains. Naturally occurring recombinant HIV strains have been found in infected patients in regions of the world where multiple genotypic variants cocirculate. One recombinant HIV strain has spread rapidly to millions of persons in Southeast Asia. Recombination is a mechanism whereby high level and multidrug-resistant strains may be generated in individual treated patients. Recombination also poses theoretical problems for the development of a safe HIV vaccine. Certain features of HIV replication, such as syncytium formation and transactivation, may be best understood as components of a sexual reproductive cycle. Recombination may be an important HIV evolutionary strategy.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Burke, DSdonburke@pitt.eduDONBURKE
Centers: Other Centers, Institutes, or Units > Center for Vaccine Research
Date: July 1997
Date Type: Publication
Journal or Publication Title: Emerg Infect Dis
Volume: 3
Number: 3
Page Range: 253 - 259
DOI or Unique Handle: 10.3201/eid0303.970301
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
Uncontrolled Keywords: Animals, Biological Evolution, Cytopathogenic Effect, Viral, Drug Resistance, Multiple, HIV Infections, HIV-1, Humans, Recombination, Genetic, Superinfection, Transcriptional Activation, Virus Replication
ISSN: 1080-6040
Date Deposited: 08 May 2015 15:10
Last Modified: 01 Nov 2017 12:58
URI: http://d-scholarship.pitt.edu/id/eprint/24325

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