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Human immunodeficiency virus type 1 strains of subtypes B and E replicate in cutaneous dendritic cell-T-cell mixtures without displaying subtype-specific tropism

Pope, M and Frankel, SS and Mascola, JR and Trkola, A and Isdell, F and Birx, DL and Burke, DS and David, DHO and Moore, JP (1997) Human immunodeficiency virus type 1 strains of subtypes B and E replicate in cutaneous dendritic cell-T-cell mixtures without displaying subtype-specific tropism. Journal of Virology, 71 (10). 8001 - 8007. ISSN 0022-538X

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Abstract

A report that genetic subtype E human immunodeficiency virus type 1 (HIV-1) strains display a preferential tropism for Langerhans cells (epidermal dendritic cells [DCs]) compared to genetic subtype B strains suggested a possible explanation for the rapid heterosexual spread of subtype E strains in Thailand (L. E. Soto-Ramirez et al., Science 271:1291-1293, 1996). In an independent system, we applied subtype E and B isolates to skin leukocytes, since skin is a relevant model for the histologically comparable surfaces of the vagina and ectocervix. Isolates of both HIV-1 subtypes infected DC-T-cell mixtures, and no subtype-specific pattern of infection was observed. Purified DCs did not support the replication of strains of either subtype B or E. Our findings do not support the conclusion that subtype E strains have a preferential tropism for DCs, suggesting that other explanations for the rapid heterosexual spread of subtype E strains in Asia should be considered.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Pope, M
Frankel, SS
Mascola, JR
Trkola, A
Isdell, F
Birx, DL
Burke, DSdonburke@pitt.eduDONBURKE
David, DHO
Moore, JP
Centers: Other Centers, Institutes, or Units > Center for Vaccine Research
Date: 26 September 1997
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: Journal of Virology
Volume: 71
Number: 10
Page Range: 8001 - 8007
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0022-538X
Date Deposited: 08 May 2015 15:13
Last Modified: 01 Nov 2017 12:58
URI: http://d-scholarship.pitt.edu/id/eprint/24329

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