Pope, M and Frankel, SS and Mascola, JR and Trkola, A and Isdell, F and Birx, DL and Burke, DS and David, DHO and Moore, JP
(1997)
Human immunodeficiency virus type 1 strains of subtypes B and E replicate in cutaneous dendritic cell-T-cell mixtures without displaying subtype-specific tropism.
Journal of Virology, 71 (10).
8001 - 8007.
ISSN 0022-538X
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Abstract
A report that genetic subtype E human immunodeficiency virus type 1 (HIV-1) strains display a preferential tropism for Langerhans cells (epidermal dendritic cells [DCs]) compared to genetic subtype B strains suggested a possible explanation for the rapid heterosexual spread of subtype E strains in Thailand (L. E. Soto-Ramirez et al., Science 271:1291-1293, 1996). In an independent system, we applied subtype E and B isolates to skin leukocytes, since skin is a relevant model for the histologically comparable surfaces of the vagina and ectocervix. Isolates of both HIV-1 subtypes infected DC-T-cell mixtures, and no subtype-specific pattern of infection was observed. Purified DCs did not support the replication of strains of either subtype B or E. Our findings do not support the conclusion that subtype E strains have a preferential tropism for DCs, suggesting that other explanations for the rapid heterosexual spread of subtype E strains in Asia should be considered.
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Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID  |
---|
Pope, M | | | | Frankel, SS | | | | Mascola, JR | | | | Trkola, A | | | | Isdell, F | | | | Birx, DL | | | | Burke, DS | donburke@pitt.edu | DONBURKE | | David, DHO | | | | Moore, JP | | | |
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Centers: |
Other Centers, Institutes, Offices, or Units > Center for Vaccine Research |
Date: |
1 January 1997 |
Date Type: |
Publication |
Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
Journal or Publication Title: |
Journal of Virology |
Volume: |
71 |
Number: |
10 |
Page Range: |
8001 - 8007 |
DOI or Unique Handle: |
10.1128/jvi.71.10.8001-8007.1997 |
Institution: |
University of Pittsburgh |
Schools and Programs: |
School of Public Health > Epidemiology |
Refereed: |
Yes |
ISSN: |
0022-538X |
Date Deposited: |
08 May 2015 15:13 |
Last Modified: |
21 Jun 2020 02:56 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/24329 |
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