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The AG recombinant IbNG and novel strains of group M HIV-1 are common in Cameroon

Carr, JK and Torimiro, JN and Wolfe, ND and Eitel, MN and Kim, B and Sanders-Buell, E and Jagodzinski, LL and Gotte, D and Burke, DS and Birx, DL and McCutchan, FE (2001) The AG recombinant IbNG and novel strains of group M HIV-1 are common in Cameroon. Virology, 286 (1). 168 - 181. ISSN 0042-6822

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The genetic diversity of group M HIV-1 is highest in west central Africa. Blood samples from four locations in Cameroon were collected to determine the molecular epidemiology of HIV-1. The C2-V5 region of envelope was sequenced from 39 of the 40 samples collected, and 7 samples were sequenced across the genome. All strains belonged to group M of HIV-1. The circulating recombinant form CRF02_AG (IbNG) was the most common strain (22/39, 56%). Two of these were confirmed by full genome analysis. Four samples (4/39, 10%) clustered with the sub-subtype F2 and one of these was confirmed by full genome sequencing. Recombinant forms, each different but containing subtype A, accounted for the next most common form (7/39, 18%). Among these recombinants, those combining subtypes A and G were the most common (4/7, 57%). Also found were 3 subtype A, 2 subtype G, and 1 subtype B strain. Many recombination break points were shared between IbNG and the other AG recombinants, though none of these other AG recombinants included IbNG as a parent. This suggests that there was an ancestral AG recombinant that gave rise to CRF02_AG (IbNG), the successful circulating recombinant form, and to others that were less successful and are now rare. © 2001 Academic Press.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Carr, JK
Torimiro, JN
Wolfe, ND
Eitel, MN
Kim, B
Sanders-Buell, E
Jagodzinski, LL
Gotte, D
Burke, DSdonburke@pitt.eduDONBURKE
Birx, DL
McCutchan, FE
Centers: Other Centers, Institutes, Offices, or Units > Center for Vaccine Research
Date: 20 July 2001
Date Type: Publication
Journal or Publication Title: Virology
Volume: 286
Number: 1
Page Range: 168 - 181
DOI or Unique Handle: 10.1006/viro.2001.0976
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0042-6822
Date Deposited: 08 May 2015 15:14
Last Modified: 02 Feb 2019 16:57


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