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Diversity of the envelope glycoprotein among human immunodeficiency virus type 1 isolates of clade E, from Asia and Africa

McCutchan, FE and Artenstein, AW and Sanders-Buell, E and Salminen, MO and Carr, JK and Mascola, JR and Yu, XF and Nelson, KE and Khamboonruang, C and Schmitt, D and Kieny, MP and Mcneil, JG and Burke, DS (1996) Diversity of the envelope glycoprotein among human immunodeficiency virus type 1 isolates of clade E, from Asia and Africa. Journal of Virology, 70 (6). 3331 - 3338. ISSN 0022-538X

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Human immunodeficiency virus type 1 isolates of clade E, known to be largely responsible for the fulminating epidemic in Southeast Asia, have been derived exclusively from Asia and Africa. Here we provide full or partial sequences of the envelope glycoprotein gene from 13 additional clade E isolates from Asia representing patients in both early and late stages of disease. More extensive comparison of isolates within clade E by geographic locale, stage of disease, and year of isolation is now possible. The genetic diversity of clade E isolates from Asia, particularly among those derived from early-stage patients, is restricted compared with African isolates (mean interisolate distances in gp120, 5.4 and 20.2%, respectively). However, patients hospitalized with AIDS-related illnesses in Thailand harbored clade E isolates exhibiting broader interisolate diversity and with highly heterogeneous third hypervariable loop sequences. An additional pair of cysteine residues, predicting a novel disulfide bridge and present in 80% of clade E isolates from Asia, was uniformly absent from six African isolates. Clade E isolates in Thailand from early-stage subjects continue to be genetically similar to potential vaccine prototype strains, providing a favorable environment for the evaluation of genotype E candidate vaccines. However, evidence of increasing interisolate diversity is appearing among late-stage patients in Asia. This diversification of the clade E virus, if sustained, may impact preventive vaccine development strategies.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
McCutchan, FE
Artenstein, AW
Sanders-Buell, E
Salminen, MO
Carr, JK
Mascola, JR
Yu, XF
Nelson, KE
Khamboonruang, C
Schmitt, D
Kieny, MP
Mcneil, JG
Burke, DSdonburke@pitt.eduDONBURKE
Centers: Other Centers, Institutes, Offices, or Units > Center for Vaccine Research
Date: 1 December 1996
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: Journal of Virology
Volume: 70
Number: 6
Page Range: 3331 - 3338
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0022-538X
Date Deposited: 07 May 2015 20:43
Last Modified: 05 Jan 2021 15:55


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