Evans, JS and Nims, T and Cooley, J and Bradley, W and Jagodzinski, L and Zhou, S and Melcher, GP and Burke, DS and Vahey, M
(1997)
Serum levels of virus burden in early-stage human immunodeficiency virus type 1 disease in women.
Journal of Infectious Diseases, 175 (4).
795 - 800.
ISSN 0022-1899
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Abstract
The fundamental clinical, viral, and immunologic features of early- stage human immunodeficiency virus type 1 (HIV-1) disease were examined in a seroprevalent cohort of 28 men and 14 women assessed longitudinally at three equally dispersed time points over a mean of 43 months. There were no gender differences in the relative risk of developing AIDS-defining end points or death. The median serum RNA levels assessed at the three study time points were 3.3-, 4.9-, and 1.5-fold lower, respectively, in women than in men. This suggests that while serum virus load may be as powerful a correlate of disease status in women as it is in men, the absolute values of the virus levels may be different in the 2 populations. These observations may have implications for the interpretation of levels of virus burden in women for the assessment of disease progression, transmission, and treatment.
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Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID  |
---|
Evans, JS | | | | Nims, T | | | | Cooley, J | | | | Bradley, W | | | | Jagodzinski, L | | | | Zhou, S | | | | Melcher, GP | | | | Burke, DS | donburke@pitt.edu | DONBURKE | | Vahey, M | | | |
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Centers: |
Other Centers, Institutes, Offices, or Units > Center for Vaccine Research |
Date: |
1 January 1997 |
Date Type: |
Publication |
Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
Journal or Publication Title: |
Journal of Infectious Diseases |
Volume: |
175 |
Number: |
4 |
Page Range: |
795 - 800 |
DOI or Unique Handle: |
10.1086/513973 |
Institution: |
University of Pittsburgh |
Schools and Programs: |
Graduate School of Public Health > Epidemiology |
Refereed: |
Yes |
ISSN: |
0022-1899 |
Date Deposited: |
08 May 2015 15:22 |
Last Modified: |
02 Feb 2019 16:57 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/24341 |
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