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Serum levels of virus burden in early-stage human immunodeficiency virus type 1 disease in women

Evans, JS and Nims, T and Cooley, J and Bradley, W and Jagodzinski, L and Zhou, S and Melcher, GP and Burke, DS and Vahey, M (1997) Serum levels of virus burden in early-stage human immunodeficiency virus type 1 disease in women. Journal of Infectious Diseases, 175 (4). 795 - 800. ISSN 0022-1899

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The fundamental clinical, viral, and immunologic features of early- stage human immunodeficiency virus type 1 (HIV-1) disease were examined in a seroprevalent cohort of 28 men and 14 women assessed longitudinally at three equally dispersed time points over a mean of 43 months. There were no gender differences in the relative risk of developing AIDS-defining end points or death. The median serum RNA levels assessed at the three study time points were 3.3-, 4.9-, and 1.5-fold lower, respectively, in women than in men. This suggests that while serum virus load may be as powerful a correlate of disease status in women as it is in men, the absolute values of the virus levels may be different in the 2 populations. These observations may have implications for the interpretation of levels of virus burden in women for the assessment of disease progression, transmission, and treatment.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Evans, JS
Nims, T
Cooley, J
Bradley, W
Jagodzinski, L
Zhou, S
Melcher, GP
Burke, DSdonburke@pitt.eduDONBURKE
Vahey, M
Centers: Other Centers, Institutes, Offices, or Units > Center for Vaccine Research
Date: 1 January 1997
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: Journal of Infectious Diseases
Volume: 175
Number: 4
Page Range: 795 - 800
DOI or Unique Handle: 10.1086/513973
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0022-1899
Date Deposited: 08 May 2015 15:22
Last Modified: 02 Feb 2019 16:57


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