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Patterns of virus burden and T cell phenotype are established early and are correlated with the rate of disease progression in human immunodeficiency virus type 1-infected persons

Wong, MT and Dolan, MJ and Kozlow, E and Doe, R and Melcher, GP and Burke, DS and Neal Boswell, R and Vahey, M (1996) Patterns of virus burden and T cell phenotype are established early and are correlated with the rate of disease progression in human immunodeficiency virus type 1-infected persons. Journal of Infectious Diseases, 173 (4). 877 - 887. ISSN 0022-1899

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Abstract

Human immunodeficiency virus (HIV)-1 DNA and RNA levels and T lymphocyte cell surface markers were measured in blood serum and cell fractions from asymptomatic infected patients to find novel virologic and immunologic features in early disease predictive of subsequent clinical disease course. Thirty-two patients with rapid disease progression (rapid CD4+ cell loss and progression to clinical AIDS) were compared with 25 patients with stable infections (constant or rising CD4+ cell counts, no clinical disease manifestations). All HIV-1 burdens measured by polymerase chain reaction were consistently higher in specimens from rapid progressors than slow progressors. For each patient, virus burden remained relatively constant throughout the study period (mean, 42-44 months). Flow cytometry also disclosed stable lymphocyte immunophenotype patterns that correlated strongly with subsequent rapid progression to clinical disease. Thus, in early HIV-1 infection, a constellation of high virus burden and in vivo costimulatory antigen and lymphocyte activation abnormalities is predictive of a rapid disease course.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Wong, MT
Dolan, MJ
Kozlow, E
Doe, R
Melcher, GP
Burke, DSdonburke@pitt.eduDONBURKE
Neal Boswell, R
Vahey, M
Centers: Other Centers, Institutes, Offices, or Units > Center for Vaccine Research
Date: 1 January 1996
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: Journal of Infectious Diseases
Volume: 173
Number: 4
Page Range: 877 - 887
DOI or Unique Handle: 10.1093/infdis/173.4.877
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0022-1899
Date Deposited: 07 May 2015 20:41
Last Modified: 22 Jun 2021 13:56
URI: http://d-scholarship.pitt.edu/id/eprint/24352

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