Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Seroprevalence and distribution of Flaviviridae, Togaviridae, and Bunyaviridae arboviral infections in rural Cameroonian adults

Kuniholm, MH and Wolfe, ND and Huang, CYH and Mpoudi-Ngole, E and Tamoufe, U and Burke, DS and Gubler, DJ (2006) Seroprevalence and distribution of Flaviviridae, Togaviridae, and Bunyaviridae arboviral infections in rural Cameroonian adults. American Journal of Tropical Medicine and Hygiene, 74 (6). 1078 - 1083. ISSN 0002-9637

[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)


Arboviruses from the families Flaviviridae, Togaviridae, and Bunyaviridae are suspected to cause widespread morbidity in sub-Saharan African populations, but little research been done to document the burden and distribution of these pathogens. We tested serum samples from 256 Cameroonian adults from nine rural villages for the presence of Dengue-2 (DEN-2), West Nile (WN), Yellow fever (YF), Chikungunya (CHIK), O'nyong-nyong (ONN), Sindbis (SIN), and Tahyna (TAH) infection using standard plaque-reduction neutralization tests (PRNT). Of these samples, 12.5% were DEN-2 positive, 6.6% were WN positive, 26.9% were YF positive, 46.5% were CHIK seropositive, 47.7% were ONN positive, 7.8% were SIN positive, and 36.3% were TAH positive. DEN-2, YF, and CHIK seroprevalence rates were lower among individuals living in dwellings with grass or thatched roofs versus corrugated tin and in villages isolated from urban centers. Seroprevalence rates of YF and CHIK increased with age. These results suggest that inter-epidemic arboviral infection is common in central African populations. Copyright © 2006 by The American Society of Tropical Medicine and Hygiene.


Social Networking:
Share |


Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Kuniholm, MH
Wolfe, ND
Huang, CYH
Mpoudi-Ngole, E
Tamoufe, U
Burke, DSdonburke@pitt.eduDONBURKE
Gubler, DJ
Centers: Other Centers, Institutes, Offices, or Units > Center for Vaccine Research
Date: 1 January 2006
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: American Journal of Tropical Medicine and Hygiene
Volume: 74
Number: 6
Page Range: 1078 - 1083
DOI or Unique Handle: 10.4269/ajtmh.2006.74.1078
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0002-9637
Date Deposited: 07 May 2015 20:39
Last Modified: 19 Jul 2020 12:55


Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item