Single versus multi-dose vaccine vials: An economic computational model

Lee, BY and Norman, BA and Assi, TM and Chen, SI and Bailey, RR and Rajgopal, J and Brown, ST and Wiringa, AE and Burke, DS (2010) Single versus multi-dose vaccine vials: An economic computational model. Vaccine, 28 (32). 5292 - 5300. ISSN 0264-410X

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Abstract

Single-dose vaccine formats can prevent clinic-level vaccine wastage but may incur higher production, medical waste disposal, and storage costs than multi-dose formats. To help guide vaccine developers, manufacturers, distributors, and purchasers, we developed a computational model to predict the potential economic impact of various single-dose versus multi-dose measles (MEA), hemophilus influenzae type B (Hib), Bacille Calmette-Guérin (BCG), yellow fever (YF), and pentavalent (DTP-HepB-Hib) vaccine formats. Lower patient demand favors fewer dose formats. The mean daily patient arrival thresholds for each vaccine format are as follows: for the MEA vaccine, 2 patients/day (below which the single-dose vial and above which the 10-dose vial are least costly); BCG vaccine, 6 patients/day (below, 10-dose vial; above, 20-dose vial); Hib vaccine, 5 patients/day (below, single-dose vial; above, 10-dose vial); YF vaccine, 33 patients/day (below, 5-dose vials; above 50-dose vial); and DTP-HepB-Hib vaccine, 5 patients/day (below, single-dose vial; above, 10-dose vial). © 2010 Elsevier Ltd.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Lee, BY byl1@pitt.edu BYL1 Norman, BA banorman@pitt.edu BANORMAN Assi, TM Chen, SI Bailey, RR Rajgopal, J j.rajgopal@pitt.edu GUNNER1 0000-0001-7730-8749 Brown, ST Wiringa, AE aew29@pitt.edu AEW29 Burke, DS donburke@pitt.edu DONBURKE
Centers:	Other Centers, Institutes, Offices, or Units > Center for Vaccine Research
Date:	1 July 2010
Date Type:	Publication
Journal or Publication Title:	Vaccine
Volume:	28
Number:	32
Page Range:	5292 - 5300
DOI or Unique Handle:	10.1016/j.vaccine.2010.05.048
Schools and Programs:	School of Public Health > Biostatistics School of Public Health > Epidemiology School of Medicine > Biomedical Informatics School of Medicine > Medicine Swanson School of Engineering > Industrial Engineering
Refereed:	Yes
ISSN:	0264-410X
Date Deposited:	07 May 2015 20:38
Last Modified:	28 Jan 2021 19:55
URI:	http://d-scholarship.pitt.edu/id/eprint/24362

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