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Single versus multi-dose vaccine vials: An economic computational model

Lee, BY and Norman, BA and Assi, TM and Chen, SI and Bailey, RR and Rajgopal, J and Brown, ST and Wiringa, AE and Burke, DS (2010) Single versus multi-dose vaccine vials: An economic computational model. Vaccine, 28 (32). 5292 - 5300. ISSN 0264-410X

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Single-dose vaccine formats can prevent clinic-level vaccine wastage but may incur higher production, medical waste disposal, and storage costs than multi-dose formats. To help guide vaccine developers, manufacturers, distributors, and purchasers, we developed a computational model to predict the potential economic impact of various single-dose versus multi-dose measles (MEA), hemophilus influenzae type B (Hib), Bacille Calmette-Guérin (BCG), yellow fever (YF), and pentavalent (DTP-HepB-Hib) vaccine formats. Lower patient demand favors fewer dose formats. The mean daily patient arrival thresholds for each vaccine format are as follows: for the MEA vaccine, 2 patients/day (below which the single-dose vial and above which the 10-dose vial are least costly); BCG vaccine, 6 patients/day (below, 10-dose vial; above, 20-dose vial); Hib vaccine, 5 patients/day (below, single-dose vial; above, 10-dose vial); YF vaccine, 33 patients/day (below, 5-dose vials; above 50-dose vial); and DTP-HepB-Hib vaccine, 5 patients/day (below, single-dose vial; above, 10-dose vial). © 2010 Elsevier Ltd.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Lee, BYbyl1@pitt.eduBYL1
Norman, BAbanorman@pitt.eduBANORMAN
Assi, TM
Chen, SI
Bailey, RR
Rajgopal, Jj.rajgopal@pitt.eduGUNNER10000-0001-7730-8749
Brown, ST
Wiringa, AEaew29@pitt.eduAEW29
Burke, DSdonburke@pitt.eduDONBURKE
Centers: Other Centers, Institutes, Offices, or Units > Center for Vaccine Research
Date: 1 July 2010
Date Type: Publication
Journal or Publication Title: Vaccine
Volume: 28
Number: 32
Page Range: 5292 - 5300
DOI or Unique Handle: 10.1016/j.vaccine.2010.05.048
Schools and Programs: School of Public Health > Biostatistics
School of Public Health > Epidemiology
School of Medicine > Biomedical Informatics
School of Medicine > Medicine
Swanson School of Engineering > Industrial Engineering
Refereed: Yes
ISSN: 0264-410X
Date Deposited: 07 May 2015 20:38
Last Modified: 28 Jan 2021 19:55


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