Sintasath, DM and Wolfe, ND and LeBreton, M and Jia, H and Garcia, AD and Diffo, JLD and Tamoufe, U and Carr, JK and Folks, TM and Mpoudi-Ngole, E and Burke, DS and Heneine, W and Switzer, WM
(2009)
Simian T-lymphotropic virus diversity among nonhuman primates, Cameroon.
Emerging Infectious Diseases, 15 (2).
175 - 184.
ISSN 1080-6040
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Abstract
Cross-species transmission of retroviruses is common in Cameroon. To determine risk for simian T-cell lympho- tropic virus (STLV) transmission from nonhuman primates to hunters, we examined 170 hunter-collected dried blood spots (DBS) from 12 species for STLV. PCR with generic tax and group-specific long terminal repeat primers showed that 12 (7%) specimens from 4 nonhuman primate species were infected with STLV. Phylogenetic analyses showed broad diversity of STLV, including novel STLV-1 and STLV-3 sequences and a highly divergent STLV-3 subtype found in Cercopithecus mona and C. nictitans monkeys. Screening of peripheral blood mononuclear cell DNA from 63 HTLV- seroreactive, PCR-negative hunters did not identify human infections with this divergent STLV-3. Therefore, hunter- collected DBS can effectively capture STLV diversity at the point where pathogen spillover occurs. Broad screening using this relatively easy collection strategy has potential for large-scale monitoring of retrovirus cross-species transmission among highly exposed human populations.
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Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID  |
---|
Sintasath, DM | | | | Wolfe, ND | | | | LeBreton, M | | | | Jia, H | | | | Garcia, AD | | | | Diffo, JLD | | | | Tamoufe, U | | | | Carr, JK | | | | Folks, TM | | | | Mpoudi-Ngole, E | | | | Burke, DS | donburke@pitt.edu | DONBURKE | | Heneine, W | | | | Switzer, WM | | | |
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Centers: |
Other Centers, Institutes, Offices, or Units > Center for Vaccine Research |
Date: |
1 February 2009 |
Date Type: |
Publication |
Journal or Publication Title: |
Emerging Infectious Diseases |
Volume: |
15 |
Number: |
2 |
Page Range: |
175 - 184 |
DOI or Unique Handle: |
10.3201/eid1502.080584 |
Schools and Programs: |
Graduate School of Public Health > Epidemiology |
Refereed: |
Yes |
ISSN: |
1080-6040 |
Date Deposited: |
07 May 2015 20:02 |
Last Modified: |
02 Feb 2019 16:57 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/24368 |
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