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Simian T-lymphotropic virus diversity among nonhuman primates, Cameroon

Sintasath, DM and Wolfe, ND and LeBreton, M and Jia, H and Garcia, AD and Diffo, JLD and Tamoufe, U and Carr, JK and Folks, TM and Mpoudi-Ngole, E and Burke, DS and Heneine, W and Switzer, WM (2009) Simian T-lymphotropic virus diversity among nonhuman primates, Cameroon. Emerging Infectious Diseases, 15 (2). 175 - 184. ISSN 1080-6040

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Abstract

Cross-species transmission of retroviruses is common in Cameroon. To determine risk for simian T-cell lympho- tropic virus (STLV) transmission from nonhuman primates to hunters, we examined 170 hunter-collected dried blood spots (DBS) from 12 species for STLV. PCR with generic tax and group-specific long terminal repeat primers showed that 12 (7%) specimens from 4 nonhuman primate species were infected with STLV. Phylogenetic analyses showed broad diversity of STLV, including novel STLV-1 and STLV-3 sequences and a highly divergent STLV-3 subtype found in Cercopithecus mona and C. nictitans monkeys. Screening of peripheral blood mononuclear cell DNA from 63 HTLV- seroreactive, PCR-negative hunters did not identify human infections with this divergent STLV-3. Therefore, hunter- collected DBS can effectively capture STLV diversity at the point where pathogen spillover occurs. Broad screening using this relatively easy collection strategy has potential for large-scale monitoring of retrovirus cross-species transmission among highly exposed human populations.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Sintasath, DM
Wolfe, ND
LeBreton, M
Jia, H
Garcia, AD
Diffo, JLD
Tamoufe, U
Carr, JK
Folks, TM
Mpoudi-Ngole, E
Burke, DSdonburke@pitt.eduDONBURKE
Heneine, W
Switzer, WM
Centers: Other Centers, Institutes, Offices, or Units > Center for Vaccine Research
Date: 1 February 2009
Date Type: Publication
Journal or Publication Title: Emerging Infectious Diseases
Volume: 15
Number: 2
Page Range: 175 - 184
DOI or Unique Handle: 10.3201/eid1502.080584
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
ISSN: 1080-6040
Date Deposited: 07 May 2015 20:02
Last Modified: 02 Feb 2019 16:57
URI: http://d-scholarship.pitt.edu/id/eprint/24368

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