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Genetic, antigenic and serologic characterization of human immunodeficiency virus type 1 from Indonesia

Porter, KR and Mascola, JR and Hupudio, H and Ewing, D and VanCott, TC and Anthony, RL and Corwin, AL and Widodo, S and Ertono, S and McCutchan, FE and Burke, DS and Hayes, CG and Wignall, FS and Graham, RR (1997) Genetic, antigenic and serologic characterization of human immunodeficiency virus type 1 from Indonesia. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 14 (1). 1 - 6. ISSN 1077-9450

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Abstract

To examine the genetic and antigenic characteristics of HIV-1 in Indonesia, samples from 19 HIV-positive volunteers were studied. By a combination of PCR typing and DNA sequence analysis, 12 of the 19 volunteers were determined to be infected with HIV-1 clade B and seven with clade E. Six of the seven Indonesian clade E isolates were from volunteers associated with the Indonesian Military during a peacekeeping mission in Cambodia. Infectivity reduction neutralization assays showed that the Indonesian E viruses were effectively neutralized by Thailand clade E HIV-1 antisera but not by U.S. clade B antisera. The Indonesian clade B virus tested was neutralized by U.S. clade B antisera and not by the Thailand E antisera. Using a previously described serologic typing ELISA based on clade B and E V3 peptides, genetic clade was accurately determined in eight of eight sera tested. This is the first report of the genetic and antigenic analysis of HIV-1 isolates from Indonesia. The data indicate that at least two genetic and antigenic HIV-1 clades (clade E and B) circulate in Indonesia.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Porter, KR
Mascola, JR
Hupudio, H
Ewing, D
VanCott, TC
Anthony, RL
Corwin, AL
Widodo, S
Ertono, S
McCutchan, FE
Burke, DSdonburke@pitt.eduDONBURKE
Hayes, CG
Wignall, FS
Graham, RR
Centers: Other Centers, Institutes, or Units > Center for Vaccine Research
Date: 1 January 1997
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Volume: 14
Number: 1
Page Range: 1 - 6
DOI or Unique Handle: 10.1097/00042560-199701010-00001
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
ISSN: 1077-9450
Date Deposited: 07 May 2015 19:59
Last Modified: 09 Dec 2017 14:56
URI: http://d-scholarship.pitt.edu/id/eprint/24372

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