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Revealing the microscale spatial signature of dengue transmission and immunity in an urban population

Salje, H and Lessler, J and Endy, TP and Curriero, FC and Gibbons, RV and Nisalak, A and Nimmannitya, S and Kalayanarooj, S and Jarman, RG and Thomas, SJ and Burke, DS and Cummings, DAT (2012) Revealing the microscale spatial signature of dengue transmission and immunity in an urban population. Proceedings of the National Academy of Sciences of the United States of America, 109 (24). 9535 - 9538. ISSN 0027-8424

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Abstract

It is well-known that the distribution of immunity in a population dictates the future incidence of infectious disease, but this process is generally understood at individual or macroscales. For example, herd immunity to multiple pathogens has been observed at national and city levels. However, the effects of population immunity have not previously been shown at scales smaller than the city (e.g., neighborhoods). In particular, no study has shownlong-termeffects of population immunity at scales consistent with the spatial scale of person-to-person transmission. Here, we use the location of dengue patients' homes in Bangkok with the serotype of the infecting pathogen to investigate the spatiotemporal distribution of disease risk at small spatial scales over a 5-y period. We find evidence for localized transmission at distances of under 1 km. We also observe patterns of spatiotemporal dependence consistent with the expected impacts of homotypic immunity, heterotypic immunity, and immune enhancement of disease at these distances. Our observations indicate that immunological memory of dengue serotypes occurs at the neighborhood level in this large urban setting. These methods have broad applications to studying the spatiotemporal structure of disease risk where pathogen serotype or genetic information is known.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Salje, H
Lessler, J
Endy, TP
Curriero, FC
Gibbons, RV
Nisalak, A
Nimmannitya, S
Kalayanarooj, S
Jarman, RG
Thomas, SJ
Burke, DSdonburke@pitt.eduDONBURKE
Cummings, DAT
Centers: Other Centers, Institutes, Offices, or Units > Center for the Neural Basis of Cognition
Date: 12 June 2012
Date Type: Publication
Journal or Publication Title: Proceedings of the National Academy of Sciences of the United States of America
Volume: 109
Number: 24
Page Range: 9535 - 9538
DOI or Unique Handle: 10.1073/pnas.1120621109
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0027-8424
Date Deposited: 07 May 2015 19:50
Last Modified: 02 Feb 2019 16:57
URI: http://d-scholarship.pitt.edu/id/eprint/24385

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