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Impact of introducing the pneumococcal and rotavirus vaccines into the routine immunization program in Niger

Lee, BY and Assi, TM and Rajgopal, J and Norman, BA and Chen, SI and Brown, ST and Slayton, RB and Kone, S and Kenea, H and Welling, JS and Connor, DL and Wateska, AR and Jana, A and Wiringa, AE and Van Panhuis, WG and Burke, DS (2012) Impact of introducing the pneumococcal and rotavirus vaccines into the routine immunization program in Niger. American Journal of Public Health, 102 (2). 269 - 276. ISSN 0090-0036

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Objectives. We investigated whether introducing the rotavirus and pneumococcal vaccines, which are greatly needed in West Africa, would overwhelm existing supply chains (i.e., the series of steps required to get a vaccine from the manufacturers to the target population) in Niger. Methods. As part of the Bill and Melinda Gates Foundation-funded Vaccine Modeling Initiative, we developed a computational model to determine the impact of introducing these new vaccines to Niger's Expanded Program on Immunization vaccine supply chain. Results. Introducing either the rotavirus vaccine or the 7-valent pneumococcal conjugate vaccine could overwhelm available storage and transport refrigerator space, creating bottlenecks that would prevent the flow of vaccines down to the clinics. As a result, the availability of all World Health Organization Expanded Program on Immunization vaccines to patients might decrease from an average of 69% to 28.2% (range=10%-51%). Addition of refrigerator and transport capacity could alleviate this bottleneck. Conclusions. Our results suggest that the effects on the vaccine supply chain should be considered when introducing a new vaccine and that computational models can help assess evolving needs and prevent problems with vaccine delivery.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Lee, BYbyl1@pitt.eduBYL1
Assi, TM
Rajgopal, Jj.rajgopal@pitt.eduGUNNER10000-0001-7730-8749
Norman, BAbanorman@pitt.eduBANORMAN
Chen, SI
Brown, ST
Slayton, RB
Kone, S
Kenea, H
Welling, JS
Connor, DL
Wateska, AR
Jana, A
Wiringa, AEaew29@pitt.eduAEW29
Van Panhuis, WGwilbert.van.panhuis@pitt.eduWAV10
Burke, DSdonburke@pitt.eduDONBURKE
Centers: Other Centers, Institutes, Offices, or Units > Center for Vaccine Research
Date: 1 February 2012
Date Type: Publication
Journal or Publication Title: American Journal of Public Health
Volume: 102
Number: 2
Page Range: 269 - 276
DOI or Unique Handle: 10.2105/ajph.2011.300218
Schools and Programs: School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0090-0036
Date Deposited: 07 May 2015 19:39
Last Modified: 11 May 2021 11:56


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