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Cross-clade reactivity of HIV-1-specific T-cell responses in HIV-1-infected individuals from Botswana and Cameroon

Gupta, SB and Mast, CT and Wolfe, ND and Novitsky, V and Dubey, SA and Kallas, EG and Schechter, M and Mbewe, B and Vardas, E and Pitisuttithum, P and Burke, D and Freed, D and Mogg, R and Coplan, PM and Condra, JH and Long, RS and Anderson, K and Casimiro, DR and Shiver, JW and Straus, WL (2006) Cross-clade reactivity of HIV-1-specific T-cell responses in HIV-1-infected individuals from Botswana and Cameroon. Journal of Acquired Immune Deficiency Syndromes, 42 (2). 135 - 139. ISSN 1525-4135

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An effective HIV type 1 (HIV-1) vaccine will likely require elicitation of broadly reactive cell-mediated immune (CMI) responses against divergent HIV-1 clades. We compared anti-HIV-1 T-cell immune responses among 363 unvaccinated adults infected with diverse HIV-1 clades. Response rates to clade B Gag and/or clade B Nef in Botswana (95%) and Cameroon (98%) were similar when compared with those in countries previously studied, including Brazil (92%), Thailand (96%), South Africa (96%), Malawi (100%), and the United States (100%). Substantial cross-clade cell-mediated immune responses in Botswana and Cameroon confirm previous findings in a larger, more genetically diverse collection of HIV-1 samples. Copyright © 2006 by Lippincott Williams & Wilkins.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Gupta, SB
Mast, CT
Wolfe, ND
Novitsky, V
Dubey, SA
Kallas, EG
Schechter, M
Mbewe, B
Vardas, E
Pitisuttithum, P
Burke, Ddonburke@pitt.eduDONBURKE
Freed, D
Mogg, R
Coplan, PM
Condra, JH
Long, RS
Anderson, K
Casimiro, DR
Shiver, JW
Straus, WL
Centers: Other Centers, Institutes, Offices, or Units > Center for Vaccine Research
Date: 1 June 2006
Date Type: Publication
Journal or Publication Title: Journal of Acquired Immune Deficiency Syndromes
Volume: 42
Number: 2
Page Range: 135 - 139
DOI or Unique Handle: 10.1097/01.qai.0000223017.01568.e7
Schools and Programs: School of Public Health > Epidemiology
Refereed: Yes
ISSN: 1525-4135
Date Deposited: 07 May 2015 19:27
Last Modified: 02 Feb 2019 16:57


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