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Economic value of dengue vaccine in Thailand

Lee, BY and Connor, DL and Kitchen, SB and Bacon, KM and Shah, M and Brown, ST and Bailey, RR and Laosiritaworn, Y and Burke, DS and Cummings, DAT (2011) Economic value of dengue vaccine in Thailand. American Journal of Tropical Medicine and Hygiene, 84 (5). 764 - 772. ISSN 0002-9637

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With several candidate dengue vaccines under development, this is an important time to help stakeholders (e.g., policy makers, scientists, clinicians, and manufacturers) better understand the potential economic value (cost-effectiveness) of a dengue vaccine, especially while vaccine characteristics and strategies might be readily altered. We developed a decision analytic Markov simulation model to evaluate the potential health and economic value of administering a dengue vaccine to an individual (≤ 1 year of age) in Thailand from the societal perspective. Sensitivity analyses evaluated the effects of ranging various vaccine (e.g., cost, efficacy, side effect), epidemiological (dengue risk), and disease (treatment-seeking behavior) characteristics. A ≥ 50% efficacious vaccine was highly cost-effective [< 1x per capita gross domestic product (GDP) ($4,289)] up to a total vaccination cost of $60 and cost-effective [< 3x per capita GDP ($12,868)] up to a total vaccination cost of $200. When the total vaccine series was $1.50, many scenarios were cost saving. Copyright © 2011 by The American Society of Tropical Medicine and Hygiene.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Lee, BYbyl1@pitt.eduBYL1
Connor, DL
Kitchen, SB
Bacon, KM
Shah, M
Brown, ST
Bailey, RR
Laosiritaworn, Y
Burke, DSdonburke@pitt.eduDONBURKE
Cummings, DAT
Centers: Other Centers, Institutes, Offices, or Units > Center for Vaccine Research
Date: 1 May 2011
Date Type: Publication
Journal or Publication Title: American Journal of Tropical Medicine and Hygiene
Volume: 84
Number: 5
Page Range: 764 - 772
DOI or Unique Handle: 10.4269/ajtmh.2011.10-0624
Schools and Programs: Graduate School of Public Health > Biostatistics
Graduate School of Public Health > Epidemiology
School of Medicine > Biomedical Informatics
School of Medicine > Medicine
Refereed: Yes
ISSN: 0002-9637
Date Deposited: 07 May 2015 19:26
Last Modified: 02 Feb 2019 16:57


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