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Interactions between serotypes of dengue highlight epidemiological impact of cross-immunity

Reich, NG and Shrestha, S and King, AA and Rohani, P and Lessler, J and Kalayanarooj, S and Yoon, IK and Gibbons, RV and Burke, DS and Cummings, DAT (2013) Interactions between serotypes of dengue highlight epidemiological impact of cross-immunity. Journal of the Royal Society Interface, 10 (86). ISSN 1742-5689

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Dengue, a mosquito-borne virus of humans, infects over 50 million people annually. Infection with any of the four dengue serotypes induces protective immunity to that serotype, but does not confer long-term protection against infection by other serotypes. The immunological interactions between serotypes are of central importance in understanding epidemiological dynamics and anticipating the impact of dengue vaccines. We analysed a 38-year time series with 12 197 serotyped dengue infections from a hospital in Bangkok, Thailand. Using novel mechanistic models to represent different hypothesized immune interactions between serotypes, we found strong evidence that infection with dengue provides substantial short-term cross-protection against other serotypes (approx. 1-3 years). This is the first quantitative evidence that short-term cross-protection exists since human experimental infection studies performed in the 1950s. These findings will impact strategies for designing dengue vaccine studies, future multi-strain modelling efforts, and our understanding of evolutionary pressures in multi-strain disease systems. © 2013 The Author(s).


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Reich, NG
Shrestha, S
King, AA
Rohani, P
Lessler, J
Kalayanarooj, S
Yoon, IK
Gibbons, RV
Burke, DSdonburke@pitt.eduDONBURKE
Cummings, DAT
Centers: Other Centers, Institutes, Offices, or Units > Center for Vaccine Research
Date: 6 September 2013
Date Type: Publication
Journal or Publication Title: Journal of the Royal Society Interface
Volume: 10
Number: 86
DOI or Unique Handle: 10.1098/rsif.2013.0414
Schools and Programs: School of Public Health > Epidemiology
Refereed: Yes
ISSN: 1742-5689
Date Deposited: 07 May 2015 19:25
Last Modified: 13 Oct 2017 18:55


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