Reich, NG and Shrestha, S and King, AA and Rohani, P and Lessler, J and Kalayanarooj, S and Yoon, IK and Gibbons, RV and Burke, DS and Cummings, DAT
(2013)
Interactions between serotypes of dengue highlight epidemiological impact of cross-immunity.
Journal of the Royal Society Interface, 10 (86).
ISSN 1742-5689
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Abstract
Dengue, a mosquito-borne virus of humans, infects over 50 million people annually. Infection with any of the four dengue serotypes induces protective immunity to that serotype, but does not confer long-term protection against infection by other serotypes. The immunological interactions between serotypes are of central importance in understanding epidemiological dynamics and anticipating the impact of dengue vaccines. We analysed a 38-year time series with 12 197 serotyped dengue infections from a hospital in Bangkok, Thailand. Using novel mechanistic models to represent different hypothesized immune interactions between serotypes, we found strong evidence that infection with dengue provides substantial short-term cross-protection against other serotypes (approx. 1-3 years). This is the first quantitative evidence that short-term cross-protection exists since human experimental infection studies performed in the 1950s. These findings will impact strategies for designing dengue vaccine studies, future multi-strain modelling efforts, and our understanding of evolutionary pressures in multi-strain disease systems. © 2013 The Author(s).
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Item Type: |
Article
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Status: |
Published |
Creators/Authors: |
Creators | Email | Pitt Username | ORCID  |
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Reich, NG | | | | Shrestha, S | | | | King, AA | | | | Rohani, P | | | | Lessler, J | | | | Kalayanarooj, S | | | | Yoon, IK | | | | Gibbons, RV | | | | Burke, DS | donburke@pitt.edu | DONBURKE | | Cummings, DAT | | | |
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Centers: |
Other Centers, Institutes, Offices, or Units > Center for Vaccine Research |
Date: |
6 September 2013 |
Date Type: |
Publication |
Journal or Publication Title: |
Journal of the Royal Society Interface |
Volume: |
10 |
Number: |
86 |
DOI or Unique Handle: |
10.1098/rsif.2013.0414 |
Schools and Programs: |
School of Public Health > Epidemiology |
Refereed: |
Yes |
ISSN: |
1742-5689 |
Date Deposited: |
07 May 2015 19:25 |
Last Modified: |
13 Oct 2017 18:55 |
URI: |
http://d-scholarship.pitt.edu/id/eprint/24414 |
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