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Replacing the measles ten-dose vaccine presentation with the single-dose presentation in Thailand

Lee, BY and Assi, TM and Rookkapan, K and Connor, DL and Rajgopal, J and Sornsrivichai, V and Brown, ST and Welling, JS and Norman, BA and Chen, SI and Bailey, RR and Wiringa, AE and Wateska, AR and Jana, A and Van Panhuis, WG and Burke, DS (2011) Replacing the measles ten-dose vaccine presentation with the single-dose presentation in Thailand. Vaccine, 29 (21). 3811 - 3817. ISSN 0264-410X

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Introduced to minimize open vial wastage, single-dose vaccine vials require more storage space and therefore may affect vaccine supply chains (i.e., the series of steps and processes involved in distributing vaccines from manufacturers to patients). We developed a computational model of Thailand's Trang province vaccine supply chain to analyze the effects of switching from a ten-dose measles vaccine presentation to each of the following: a single-dose measles-mumps-rubella vaccine (which Thailand is currently considering) or a single-dose measles vaccine. While the Trang province vaccine supply chain would generally have enough storage and transport capacity to accommodate the switches, the added volume could push some locations' storage and transport space utilization close to their limits. Single-dose vaccines would allow for more precise ordering and decrease open vial waste, but decrease reserves for unanticipated demand. Moreover, the added disposal and administration costs could far outweigh the costs saved from preventing open vial wastage. © 2011 Elsevier Ltd.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Lee, BYbyl1@pitt.eduBYL1
Assi, TM
Rookkapan, K
Connor, DL
Rajgopal, Jj.rajgopal@pitt.eduGUNNER10000-0001-7730-8749
Sornsrivichai, V
Brown, ST
Welling, JS
Norman, BAbanorman@pitt.eduBANORMAN
Chen, SI
Bailey, RR
Wiringa, AEaew29@pitt.eduAEW29
Wateska, AR
Jana, A
Van Panhuis, WGwilbert.van.panhuis@pitt.eduWAV10
Burke, DSdonburke@pitt.eduDONBURKE
Centers: Other Centers, Institutes, Offices, or Units > Center for Vaccine Research
Date: 12 May 2011
Date Type: Publication
Journal or Publication Title: Vaccine
Volume: 29
Number: 21
Page Range: 3811 - 3817
DOI or Unique Handle: 10.1016/j.vaccine.2011.03.013
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0264-410X
Date Deposited: 07 May 2015 19:22
Last Modified: 11 May 2021 11:56


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