Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form

Risk factors for African tick-bite fever in rural central Africa

Ndip, LM and Biswas, HH and Nfonsam, LE and LeBreton, M and Ndip, RN and Bissong, MA and Mpoudi-Ngole, E and Djoko, C and Tamoufe, U and Prosser, AT and Burke, DS and Wolfe, ND (2011) Risk factors for African tick-bite fever in rural central Africa. American Journal of Tropical Medicine and Hygiene, 84 (4). 608 - 613. ISSN 0002-9637

[img] Plain Text (licence)
Available under License : See the attached license file.

Download (1kB)


African tick-bite fever is an emerging infectious disease caused by the spotted fever group Rickettsia, Rickettsia africae, and is transmitted by ticks of the genus Amblyomma. To determine the seroprevalence of exposure to R. africae and risk factors associated with infection, we conducted a cross-sectional study of persons in seven rural villages in distinct ecological habitats of Cameroon. We examined 903 plasma samples by using an indirect immunofluorescence assay for antibodies to R. africae and analyzed demographic and occupational data collected from questionnaires. Of the 903 persons tested, 243 (26.9%) had IgG/IgM/IgA reactive with R. africae. Persons from four of the seven village sites were significantly more likely to be seropositive (P < 0.05), and lowland forest sites tended to have higher seroprevalences. These results suggest that African tick-bite fever is common in adults in rural areas of Cameroon and that ecological factors may play a role in the acquisition of R. africae infection. Copyright © 2011 by The American Society of Tropical Medicine and Hygiene.


Social Networking:
Share |


Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Ndip, LM
Biswas, HH
Nfonsam, LE
LeBreton, M
Ndip, RN
Bissong, MA
Mpoudi-Ngole, E
Djoko, C
Tamoufe, U
Prosser, AT
Burke, DSdonburke@pitt.eduDONBURKE
Wolfe, ND
Centers: Other Centers, Institutes, Offices, or Units > Center for Vaccine Research
Date: 1 April 2011
Date Type: Publication
Journal or Publication Title: American Journal of Tropical Medicine and Hygiene
Volume: 84
Number: 4
Page Range: 608 - 613
DOI or Unique Handle: 10.4269/ajtmh.2011.10-0191
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0002-9637
Date Deposited: 07 May 2015 19:14
Last Modified: 02 Feb 2019 16:57


Monthly Views for the past 3 years

Plum Analytics

Actions (login required)

View Item View Item