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Frequency of CCR5 variants among rural populations with low HIV-1 prevalence in Cameroon

Torimiro, JN and Wolfe, ND and Thomas, A and Martin, MP and Mpoudi-Ngole, E and Tamoufe, U and Birx, DL and Carrington, M and Burke, DS and Carr, JK (2007) Frequency of CCR5 variants among rural populations with low HIV-1 prevalence in Cameroon. AIDS, 21 (4). 527 - 528. ISSN 0269-9370

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Among rural populations in Cameroon, HIV-1 prevalence is low and the genetic diversity broad. An unusual population-level genetic background may modulate this pattern of HIV infection. We examined HIV-1 prevalence, CCR5Δ32 and CCR5 promoter -2459 G genotype frequency among 1390 rural inhabitants. No individual was identified with the CCR5Δ32 allele, but homozygotes for the CCR5 promoter variant -2459G (27.5%) were relatively common. A seroprevalence of 3.1% of HIV-1 was reported. © 2007 Lippincott Williams & Wilkins, Inc.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Torimiro, JN
Wolfe, ND
Thomas, A
Martin, MP
Mpoudi-Ngole, E
Tamoufe, U
Birx, DL
Carrington, M
Burke, DSdonburke@pitt.eduDONBURKE
Carr, JK
Centers: Other Centers, Institutes, Offices, or Units > Center for Vaccine Research
Date: 1 February 2007
Date Type: Publication
Journal or Publication Title: AIDS
Volume: 21
Number: 4
Page Range: 527 - 528
DOI or Unique Handle: 10.1097/qad.0b013e328045c4bd
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0269-9370
Date Deposited: 06 Apr 2015 17:21
Last Modified: 02 Feb 2019 16:57


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