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A rare null allele potentially encoding a dominant-negative TRIM5α protein in Baka pygmies

Torimiro, JN and Javanbakht, H and Diaz-Griffero, F and Kim, J and Carr, JK and Carrington, M and Sawitzke, J and Burke, DS and Wolfe, ND and Dean, M and Sodroski, J (2009) A rare null allele potentially encoding a dominant-negative TRIM5α protein in Baka pygmies. Virology, 391 (1). 140 - 147. ISSN 0042-6822

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Abstract

The global acquired immunodeficiency syndrome (AIDS) pandemic is thought to have arisen by the transmission of human immunodeficiency virus (HIV-1)-like viruses from chimpanzees in southeastern Cameroon to humans. TRIM5α is a restriction factor that can decrease the susceptibility of cells of particular mammalian species to retrovirus infection. A survey of TRIM5 genes in 127 indigenous individuals from southeastern Cameroon revealed that approximately 4% of the Baka pygmies studied were heterozygous for a rare variant with a stop codon in exon 8. The predicted product of this allele, TRIM5 R332X, is truncated in the functionally important B30.2(SPRY) domain, does not restrict retrovirus infection, and acts as a dominant-negative inhibitor of wild-type human TRIM5α. Thus, some indigenous African forest dwellers potentially exhibit diminished TRIM5α function; such genetic factors, along with the high frequency of exposure to chimpanzee body fluids, may have predisposed to the initial cross-species transmission of HIV-1-like viruses. © 2009 Elsevier Inc.


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Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Torimiro, JN
Javanbakht, H
Diaz-Griffero, F
Kim, J
Carr, JK
Carrington, M
Sawitzke, J
Burke, DSdonburke@pitt.eduDONBURKE
Wolfe, ND
Dean, M
Sodroski, J
Centers: Other Centers, Institutes, Offices, or Units > Center for Vaccine Research
Date: 15 August 2009
Date Type: Publication
Journal or Publication Title: Virology
Volume: 391
Number: 1
Page Range: 140 - 147
DOI or Unique Handle: 10.1016/j.virol.2009.05.038
Schools and Programs: Graduate School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0042-6822
Date Deposited: 06 Apr 2015 17:14
Last Modified: 02 Feb 2019 16:57
URI: http://d-scholarship.pitt.edu/id/eprint/24472

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