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Contribution of the candidate genes for primary lymphedema to secondary lymphedema and chronic pain in post-mastectomy patients

Nunziato-Virga, Stephanie (2015) Contribution of the candidate genes for primary lymphedema to secondary lymphedema and chronic pain in post-mastectomy patients. Master's Thesis, University of Pittsburgh. (Unpublished)

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Secondary lymphedema is a common complication after surgical treatment, particularly after breast surgery, in which very little is understood about possible determinants. Multiple studies have been conducted to identify specific genes contributing to inherited primary lymphedema. Some of these causative genetic factors may also play a role in the development of secondary lymphedema. Among them, the GJC2 and MET genes have been identified as being associated with primary lymphedema. Further investigation using common SNP analysis of the GJC2 and MET genes was performed in patients post breast surgery, with and without secondary lymphedema to determine whether variants of either gene could be a determining factor for developing secondary lymphedema after surgical treatment. Survey data analysis addressing various psychosocial and bio-behavioral factors was also analyzed to indicate whether these candidate genes affect chronic pain and psychosocial traits in patients with secondary lymphedema compared to matched controls. Variants at rs11800309 of the GJC2 gene and patients’ Pain Catastrophizing Scores were significant (ά=.1) for predicting lymphedema. Variants of rs41737 of the MET gene was observed to have an effect on brief pain inventory, perceived stress scores, and depression scores. Variants at rs7539762 and rs11800309 of the GJC2 gene were observed to effect anxiety levels. Age was observed to be inversely proportional to all psychosocial phenotype scores. This current study has public health significance because it can help identify women who may be at an increased risk for developing secondary lymphedema after breast surgery.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Nunziato-Virga, Stephaniesrn25@pitt.eduSRN25
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Thesis AdvisorBelfer, Innainb6@pitt.eduINB6
Committee MemberFinegold, Daviddnf@pitt.eduDNF
Committee MemberShaffer, John Rjrs51@pitt.eduJRS51
Committee MemberBarmada, M Michaelbarmada@pitt.eduBARMADA
Date: 29 June 2015
Date Type: Publication
Defense Date: 31 March 2015
Approval Date: 29 June 2015
Submission Date: 6 April 2015
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 124
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Human Genetics
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: Lymphedema, GJC2, MET, Pain
Date Deposited: 29 Jun 2015 14:21
Last Modified: 15 Nov 2016 14:27


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