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Potential opportunities and perils of imperfect dengue vaccines

Rodriguez-Barraquer, I and Mier-y-Teran-Romero, L and Schwartz, IB and Burke, DS and Cummings, DAT (2014) Potential opportunities and perils of imperfect dengue vaccines. Vaccine, 32 (4). 514 - 520. ISSN 0264-410X

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Dengue vaccine development efforts have focused on the development of tetravalent vaccines. However, a recent Phase IIb trial of a tetravalent vaccine indicates a protective effect against only 3 of the 4 serotypes. While vaccines effective against a subset of serotypes may reduce morbidity and mortality, particular profiles could result in an increased number of cases due to immune enhancement and other peculiarities of dengue epidemiology. Here, we use a compartmental transmission model to assess the impact of partially effective vaccines in a hyperendemic Thai population. Crucially, we evaluate the effects that certain serotype heterogeneities may have in the presence of mass-vaccination campaigns.In the majority of scenarios explored, partially effective vaccines lead to 50% or greater reductions in the number of cases. This is true even of vaccines that we would not expect to proceed to licensure due to poor or incomplete immune responses. Our results show that a partially effective vaccine can have significant impacts on serotype distribution and mean age of cases. © 2013 The Authors.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Rodriguez-Barraquer, I
Mier-y-Teran-Romero, L
Schwartz, IB
Burke, DSdonburke@pitt.eduDONBURKE
Cummings, DAT
Centers: Other Centers, Institutes, Offices, or Units > Center for Vaccine Research
Date: 16 January 2014
Date Type: Publication
Journal or Publication Title: Vaccine
Volume: 32
Number: 4
Page Range: 514 - 520
DOI or Unique Handle: 10.1016/j.vaccine.2013.11.020
Schools and Programs: School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0264-410X
Date Deposited: 07 May 2015 18:56
Last Modified: 02 Feb 2019 16:57


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