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A model international partnership for community-based research on vaccine-preventable diseases: The Kamphaeng Phet-AFRIMS Virology Research Unit (KAVRU)

Gibbons, RV and Nisalak, A and Yoon, IK and Tannitisupawong, D and Rungsimunpaiboon, K and Vaughn, DW and Endy, TP and Innis, BL and Burke, DS and Mammen, MP and Scott, RMN and Thomas, SJ and Hoke, CH (2013) A model international partnership for community-based research on vaccine-preventable diseases: The Kamphaeng Phet-AFRIMS Virology Research Unit (KAVRU). Vaccine, 31 (41). 4487 - 4500. ISSN 0264-410X

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This paper describes an international collaboration to carry out studies that contributed to the understanding of pathogenesis, diagnosis, treatment, and prevention of several diseases of public health importance for Thailand and the United States. In Kamphaeng Phet Province, Thailand, febrile syndromes, including encephalitis, hepatitis, hemorrhagic fever, and influenza-like illnesses, occurred commonly and were clinically diagnosed, but the etiology was rarely confirmed. Since 1982, the Kamphaeng Phet Provincial Hospital, the Thai Ministry of Public Health, and the US Army Component of the Armed Forces Research Institute of Medical Sciences, along with vaccine manufacturers and universities, have collaborated on studies that evaluated and capitalized on improved diagnostic capabilities for infections caused by Japanese encephalitis, hepatitis A, dengue, and influenza viruses. The collaboration clarified clinical and epidemiological features of these infections and, in large clinical trials, demonstrated that vaccines against Japanese encephalitis and hepatitis A viruses were over 90% efficacious, supporting licensure of both vaccines. With the introduction of Japanese encephalitis vaccines in Thailand's Expanded Program on Immunization, reported encephalitis rates dropped substantially. Similarly, in the US, particularly in the military populations, rates of hepatitis A disease have dropped with the use of hepatitis A vaccine. Studies of the pathogenesis of dengue infections have increased understanding of the role of cellular immunity in responding to these infections, and epidemiological studies have prepared the province for studies of dengue vaccines. Approximately 80 publications resulted from this collaboration. Studies conducted in Kamphaeng Phet provided experience that contributed to clinical trials of hepatitis E and HIV vaccines, conducted elsewhere. To provide a base for continuing studies, The Kamphaeng Phet-AFRIMS Virology Research Unit (KAVRU) was established. This paper reviews the origins of the collaboration and the scientific observations made between 1982 and 2012. © 2013 Elsevier Ltd.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Gibbons, RV
Nisalak, A
Yoon, IK
Tannitisupawong, D
Rungsimunpaiboon, K
Vaughn, DW
Endy, TP
Innis, BL
Burke, DSdonburke@pitt.eduDONBURKE
Mammen, MP
Scott, RMN
Thomas, SJ
Hoke, CH
Centers: Other Centers, Institutes, Offices, or Units > Center for Vaccine Research
Date: 23 September 2013
Date Type: Publication
Journal or Publication Title: Vaccine
Volume: 31
Number: 41
Page Range: 4487 - 4500
DOI or Unique Handle: 10.1016/j.vaccine.2013.07.082
Schools and Programs: School of Public Health > Epidemiology
Refereed: Yes
ISSN: 0264-410X
Article Type: Review
Date Deposited: 05 May 2015 16:56
Last Modified: 02 Feb 2019 16:57


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