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Retrospective Review of Trend in Modafinil Overexposures Reported to American Poison Information Centers

Bohnenberger, Kristin A. and Krenzelok, Edward P. (2014) Retrospective Review of Trend in Modafinil Overexposures Reported to American Poison Information Centers. Asia Pacific Journal of Medical Toxicology, 3 (2). 50 - 54. ISSN 2322-2611

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Abstract

Background: Modafinil, a non-amphetamine central nervous system stimulant, is a wakefulness-promoting agent indicated for use in shift work sleep disorder, narcolepsy, and obstructive sleep apnea. The trend in modafinil overexposure over a ten-year period and the population likely to experience a resulting clinical effect is evaluated. Methods: Using data from the American Association of Poison Control Center (AAPCC) National Poison Data System (NPDS), a retrospective review of all reported modafinil overexposures over a ten-year period (2001-2010) was conducted. In order to determine whether age, reason and acuity had a role in predicting medical outcome, odds ratios (OR) were calculated using binomial logistic regression analysis. Results: There were 1,100 modafinil overexposures reported with known outcomes, of which 600 cases (54%) were women and 367 (33%) were ≤ 5 years old. Seventy-seven percent of the exposures were acute ingestions and the majority was unintentional. The number of reported modafinil exposures increased with time until 2007. Adults were more likely to have an adverse effect than children ≤ 5 years of age. Patients with an intentional overexposure were more likely to have an effect than those with an unintentional overexposure (OR = 5.2; 95% CI 3.9-7.1; P

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Bohnenberger, Kristin A.
Krenzelok, Edward P.
Date: June 2014
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: Asia Pacific Journal of Medical Toxicology
Volume: 3
Number: 2
Publisher: Mashhad University of Medical Sciences
Page Range: 50 - 54
Institution: University of Pittsburgh
Schools and Programs: School of Pharmacy > Pharmaceutical Sciences
Refereed: Yes
ISSN: 2322-2611
Article Type: Research Article
Date Deposited: 22 May 2015 22:01
Last Modified: 20 Dec 2018 00:56
URI: http://d-scholarship.pitt.edu/id/eprint/24664

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