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Sleep spindle deficits in antipsychotic-naïve early course schizophrenia and in non-psychotic first-degree relatives

Manoach, DS and Demanuele, C and Wamsley, EJ and Vangel, M and Montrose, DM and Miewald, J and Kupfer, D and Buysse, D and Stickgold, R and Keshavan, MS (2014) Sleep spindle deficits in antipsychotic-naïve early course schizophrenia and in non-psychotic first-degree relatives. Frontiers in Human Neuroscience, 8 (OCT).

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Abstract

© 2014 Manoach, Demanuele, Wamsley, Vangel, Montrose, Miewald, Kupfer, Buysse, Stickgold and Keshavan. Introduction: Chronic medicated patients with schizophrenia have marked reductions in sleep spindle activity and a correlated deficit in sleep-dependent memory consolidation. Using archival data, we investigated whether antipsychotic-naïve early course patients with schizophrenia and young non-psychotic first-degree relatives of patients with schizophrenia also show reduced sleep spindle activity and whether spindle activity correlates with cognitive function and symptoms.Method: Sleep spindles during Stage 2 sleep were compared in antipsychotic-naïve adults newly diagnosed with psychosis, young non-psychotic first-degree relatives of schizophrenia patients and two samples of healthy controls matched to the patients and relatives. The relations of spindle parameters with cognitive measures and symptom ratings were examined.Results: Early course schizophrenia patients showed significantly reduced spindle activity relative to healthy controls and to early course patients with other psychotic disorders. Relatives of schizophrenia patients also showed reduced spindle activity compared with controls. Reduced spindle activity correlated with measures of executive function in early course patients, positive symptoms in schizophrenia and IQ estimates across groups.Conclusions: Like chronic medicated schizophrenia patients, antipsychotic-naïve early course schizophrenia patients and young non-psychotic relatives of individuals with schizophrenia have reduced sleep spindle activity. These findings indicate that the spindle deficit is not an antipsychotic side-effect or a general feature of psychosis. Instead, the spindle deficit may predate the onset of schizophrenia, persist throughout its course and be an endophenotype that contributes to cognitive dysfunction.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Manoach, DS
Demanuele, C
Wamsley, EJ
Vangel, M
Montrose, DMDMM159@pitt.eduDMM159
Miewald, J
Kupfer, Ddjkupfer@pitt.eduDJKUPFER
Buysse, Dbuysse@pitt.eduBUYSSE
Stickgold, R
Keshavan, MSkeshavan@pitt.eduKESHAVAN
Date: 7 October 2014
Date Type: Publication
Journal or Publication Title: Frontiers in Human Neuroscience
Volume: 8
Number: OCT
DOI or Unique Handle: 10.3389/fnhum.2014.00762
Schools and Programs: School of Medicine > Psychiatry
Refereed: Yes
Date Deposited: 22 May 2015 21:45
Last Modified: 30 Oct 2018 14:02
URI: http://d-scholarship.pitt.edu/id/eprint/24737

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