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Drug resistance in non-B subtype HIV-1: Impact of HIV-1 reverse transcriptase inhibitors

Singh, K and Flores, JA and Kirby, KA and Neogi, U and Sonnerborg, A and Hachiya, A and Das, K and Arnold, E and McArthur, C and Parniak, M and Sarafianos, SG (2014) Drug resistance in non-B subtype HIV-1: Impact of HIV-1 reverse transcriptase inhibitors. Viruses, 6 (9). 3535 - 3562.

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Abstract

Human immunodeficiency virus (HIV) causes approximately 2.5 million new infections every year, and nearly 1.6 million patients succumb to HIV each year. Several factors, including cross-species transmission and error-prone replication have resulted in extraordinary genetic diversity of HIV groups. One of these groups, known as group M (main) contains nine subtypes (A-D, F-H and J-K) and causes ∼95% of all HIV infections. Most reported data on susceptibility and resistance to anti-HIV therapies are from subtype B HIV infections, which are prevalent in developed countries but account for only ∼12% of all global HIV infections, whereas non-B subtype HIV infections that account for ∼88% of all HIV infections are prevalent primarily in low and middle-income countries. Although the treatments for subtype B infections are generally effective against non-B subtype infections, there are differences in response to therapies. Here, we review how polymorphisms, transmission efficiency of drug-resistant strains, and differences in genetic barrier for drug resistance can differentially alter the response to reverse transcriptase-targeting therapies in various subtypes.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Singh, K
Flores, JA
Kirby, KA
Neogi, U
Sonnerborg, A
Hachiya, A
Das, K
Arnold, E
McArthur, C
Parniak, Mmap167@pitt.eduMAP167
Sarafianos, SG
Date: 24 September 2014
Date Type: Publication
Journal or Publication Title: Viruses
Volume: 6
Number: 9
Page Range: 3535 - 3562
DOI or Unique Handle: 10.3390/v6093535
Schools and Programs: School of Medicine > Microbiology and Molecular Genetics
Refereed: Yes
Article Type: Review
Date Deposited: 22 May 2015 21:39
Last Modified: 27 Mar 2021 10:55
URI: http://d-scholarship.pitt.edu/id/eprint/24748

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