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Dendritic cells: Key players in human herpesvirus 8 infection and pathogenesis

Campbell, DM and Rappocciolo, G and Jenkins, FJ and Rinaldo, CR (2014) Dendritic cells: Key players in human herpesvirus 8 infection and pathogenesis. Frontiers in Microbiology, 5 (AUG).

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Human herpesvirus 8 (HHV-8; Kaposi's sarcoma-associated herpesvirus) is an oncogenic gammaherpesvirus that primarily infects cells of the immune and vascular systems. HHV-8 interacts with and targets professional antigen presenting cells and influences their function. Infection alters the maturation, antigen presentation, and immune activation capabilities of certain dendritic cells (DC) despite non-robust lytic replication in these cells. DC sustains a low level of antiviral functionality during HHV-8 infection in vitro. This may explain the ability of healthy individuals to effectively control this virus without disease. Following an immune compromising event, such as organ transplantation or human immunodeficiency virus type 1 infection, a reduced cellular antiviral response against HHV-8 compounded with skewed DC cytokine production and antigen presentation likely contributes to the development of HHV-8 associated diseases, i.e., Kaposi's sarcoma and certain B cell lymphomas. In this review we focus on the role of DC in the establishment of HHV-8 primary and latent infection, the functional state of DC during HHV-8 infection, and the current understanding of the factors influencing virus-DC interactions in the context of HHV-8-associated disease.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Campbell, DM
Rappocciolo, Ggiovanna@pitt.eduGIOVANNA
Jenkins, FJfjenkins@pitt.eduFJENKINS
Rinaldo, CRRINALDO@pitt.eduRINALDO
Date: 1 January 2014
Date Type: Publication
Journal or Publication Title: Frontiers in Microbiology
Volume: 5
Number: AUG
DOI or Unique Handle: 10.3389/fmicb.2014.00452
Schools and Programs: School of Public Health > Infectious Diseases and Microbiology
School of Medicine > Pathology
Refereed: Yes
Article Type: Review
Date Deposited: 22 May 2015 21:36
Last Modified: 30 Mar 2021 11:55


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