Link to the University of Pittsburgh Homepage
Link to the University Library System Homepage Link to the Contact Us Form
D-Scholarship @ Pitt Banner and Links to Homepage

ALDH Activity Correlates with Metastatic Potential in Primary Sarcomas of Bone.

Greco, Nicholas and Schott, Trevor and Mu, Xiaodong and Rothenberg, Adam and Voigt, Clifford and McGough, Richard L and Goodman, Mark and Huard, Johnny and Weiss, Kurt R (2014) ALDH Activity Correlates with Metastatic Potential in Primary Sarcomas of Bone. J Cancer Ther, 5 (4). 331 - 338. ISSN 2151-1934

[img]
Preview
 PDF
Published Version
Available under License : See the attached license file.
Download (838kB)
[img] Plain Text (licence)
Available under License : See the attached license file.
Download (1kB)

Abstract

Osteosarcoma (OS), chondrosarcoma (CSA), and Ewings sarcoma (ES) are the most common primary malignancies of bone, and are rare diseases. As with all sarcomas, the prognosis of these diseases ultimately depends on the presence of metastatic disease. Survival is therefore closely linked with the biology and metastatic potential of a particular bone tumor's cells. Here we describe a significant correlation of aldehyde dehydrogenase (ALDH) activity and the presence/absence of distant metastases in ten consecutive cases of human bone sarcomas. Additionally, cultured human CSA cells, which are historically chemo- and radio-resistant, may be sensitive to the ALDH inhibitor, disulfiram. While it is premature to draw broad conclusions from such a small series, the importance of ALDH activity and inhibition in the metastatic potential of primary bone sarcomas should be investigated further.

Share

Citation/Export:
Social Networking:
Share |

Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Greco, Nicholas
Schott, Trevorths33@pitt.eduTHS33
Mu, Xiaodong
Rothenberg, Adam
Voigt, Clifford
McGough, Richard L
Goodman, Mark
Huard, Johnny
Weiss, Kurt Rkrw13@pitt.eduKRW13
Centers: Other Centers, Institutes, Offices, or Units > Hillman Cancer Center
Date: 31 March 2014
Date Type: Publication
Journal or Publication Title: J Cancer Ther
Volume: 5
Number: 4
Page Range: 331 - 338
DOI or Unique Handle: 10.4236/jct.2014.54040
Schools and Programs: School of Medicine > Orthopaedic Surgery
Refereed: Yes
Uncontrolled Keywords: Aldehyde Dehydrogenase, Chondrosarcoma, Ewings Sarcoma, Metastases, Osteosarcoma
ISSN: 2151-1934
Funders: NCI NIH HHS (K08 CA177927)
Date Deposited: 22 May 2015 21:13
Last Modified: 13 Oct 2017 21:57
URI: http://d-scholarship.pitt.edu/id/eprint/24781

Metrics

Monthly Views for the past 3 years

Plum Analytics

Altmetric.com

Actions (login required)

View Item View Item