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Genetic imaging of the association of oxytocin receptor gene (OXTR) polymorphisms with positive maternal parenting

Michalska, KJ and Decety, J and Liu, C and Chen, Q and Martz, ME and Jacob, S and Hipwell, AE and Lee, SS and Chronis-Tuscano, A and Waldman, ID and Lahey, BB (2014) Genetic imaging of the association of oxytocin receptor gene (OXTR) polymorphisms with positive maternal parenting. Frontiers in Behavioral Neuroscience, 8 (FEB). ISSN 1662-5153

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Abstract

Background: Well-validated models of maternal behavior in small-brain mammals posit a central role of oxytocin in parenting, by reducing stress and enhancing the reward value of social interactions with offspring. In contrast, human studies are only beginning to gain insights into how oxytocin modulates maternal behavior and affiliation. Methods: To explore associations between oxytocin receptor genes and maternal parenting behavior in humans, we conducted a genetic imaging study of women selected to exhibit a wide range of observed parenting when their children were 4-6 years old. Results: In response to child stimuli during functional magnetic resonance imaging (fMRI), hemodynamic responses in brain regions that mediate affect, reward, and social behavior were significantly correlated with observed positive parenting. Furthermore, single nucleotide polymorphisms (SNPs) (rs53576 and rs1042778) in the gene encoding the oxytocin receptor were significantly associated with both positive parenting and hemodynamic responses to child stimuli in orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), and hippocampus. Conclusions: These findings contribute to the emerging literature on the role of oxytocin in human social behavior and support the feasibility of tracing biological pathways from genes to neural regions to positive maternal parenting behaviors in humans using genetic imaging methods. © 2014 Michalska, Decety, Liu, Chen, Martz, Jacob, Hipwell, Lee, Chronis-Tuscano, Waldman and Lahey.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Michalska, KJ
Decety, J
Liu, C
Chen, Q
Martz, ME
Jacob, S
Hipwell, AEaeh5@pitt.eduAEH5
Lee, SS
Chronis-Tuscano, A
Waldman, ID
Lahey, BB
Date: 3 February 2014
Date Type: Publication
Journal or Publication Title: Frontiers in Behavioral Neuroscience
Volume: 8
Number: FEB
DOI or Unique Handle: 10.3389/fnbeh.2014.00021
Schools and Programs: School of Medicine > Psychiatry
Refereed: Yes
ISSN: 1662-5153
Date Deposited: 05 May 2015 15:14
Last Modified: 13 Oct 2017 22:58
URI: http://d-scholarship.pitt.edu/id/eprint/24876

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