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Adult Stem Cells and Diseases of Aging.

Boyette, Lisa B and Tuan, Rocky S (2014) Adult Stem Cells and Diseases of Aging. J Clin Med, 3 (1). 88 - 134. ISSN 2077-0383

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Preservation of adult stem cells pools is critical for maintaining tissue homeostasis into old age. Exhaustion of adult stem cell pools as a result of deranged metabolic signaling, premature senescence as a response to oncogenic insults to the somatic genome, and other causes contribute to tissue degeneration with age. Both progeria, an extreme example of early-onset aging, and heritable longevity have provided avenues to study regulation of the aging program and its impact on adult stem cell compartments. In this review, we discuss recent findings concerning the effects of aging on stem cells, contributions of stem cells to age-related pathologies, examples of signaling pathways at work in these processes, and lessons about cellular aging gleaned from the development and refinement of cellular reprogramming technologies. We highlight emerging therapeutic approaches to manipulation of key signaling pathways corrupting or exhausting adult stem cells, as well as other approaches targeted at maintaining robust stem cell pools to extend not only lifespan but healthspan.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Boyette, Lisa Blbb21@pitt.eduLBB21
Tuan, Rocky Srst13@pitt.eduRST13
Centers: Other Centers, Institutes, Offices, or Units > McGowan Institute for Regenerative Medicine
Date: 21 January 2014
Date Type: Publication
Journal or Publication Title: J Clin Med
Volume: 3
Number: 1
Page Range: 88 - 134
DOI or Unique Handle: 10.3390/jcm3010088
Schools and Programs: Swanson School of Engineering > Bioengineering
Refereed: Yes
Uncontrolled Keywords: FoxO, Wnt, aging, longevity, metabolic disease, oxidative stress, progeria, reprogramming, stem cells
ISSN: 2077-0383
Funders: Intramural NIH HHS (Z01 AR041131-06)
Date Deposited: 23 Apr 2015 14:27
Last Modified: 01 Nov 2017 13:57


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