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Alzheimer’s Disease review: targets for early intervention

Penderville, Joshua (2015) Alzheimer’s Disease review: targets for early intervention. Master Essay, University of Pittsburgh.

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Advances in health-related fields have brought higher life expectancy, but little progress has been made in terms of quality of life for patients with Alzheimer’s Disease (AD). With an aging population, the projected socioeconomic burden of AD is severe and of great public health importance. In order to lessen the impact of the disease, effective therapeutics are needed, but the multifactorial nature of AD impedes scientific progress. Current treatments, while having some benefit in symptom management, do not modify disease progression and have limited efficacy in later stages of AD. For most chronic conditions, earlier treatment results in a better chance of slowing or preventing disease progression. Recent clinical and laboratory findings are identifying likely upstream components of AD and proposing several approaches to therapy. The purpose of this essay is to summarize these findings, evaluate their potential for intervention, and highlight the overall barriers that persist in AD treatment.


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Item Type: Other Thesis, Dissertation, or Long Paper (Master Essay)
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Penderville, Joshuajap135@pitt.eduJAP135
ContributionContributors NameEmailPitt UsernameORCID
Committee ChairMiljkovic, IvaIVM1@pitt.eduIVM1UNSPECIFIED
Committee MemberAzzam, Pierreazzamp@upmc.eduPNA1UNSPECIFIED
Date: April 2015
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Publisher: University of Pittsburgh
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Epidemiology
Degree: MPH - Master of Public Health
Thesis Type: Master Essay
Refereed: Yes
Date Deposited: 03 Nov 2015 18:11
Last Modified: 30 Mar 2022 11:56


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