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Analysis of an immune focused targeted genetic association study in intermediate-risk Melanoma

Qian, Ying (2015) Analysis of an immune focused targeted genetic association study in intermediate-risk Melanoma. Master's Thesis, University of Pittsburgh. (Unpublished)

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Abstract

The Centers for Disease Control and Prevention (CDC) estimates that about 8,000 deaths in the United States are caused by melanoma skin cancer each year. Melanoma has become the most lethal skin cancer over the past three decades. Immunotherapies were introduced to Melanoma patients in the 60’s, and Interferon Alpha (IFN α) is one of the mostly used drugs for immunotherapy. Previous studies showed that using IFN α-2b might increase the survival rate of patients with high-risk melanoma skin cancer. However, not all patients respond to immunotherapies. So ECOG 1697 (E1697) trial was performed to compare the effect of patients obtained four-week high-dose IFN-a2b and the control group. This project utilizes a subset of the E1697 patients to search for potential immune-related genes that are associated with the prognosis of patients with localized melanoma. Both SNP and gene level analysis were conducted. This study has important public health significance because it identifies genetic factors associated with prognosis of local melanoma, which may be used to guide the treatment of this subgroup of melanoma patients in the future.


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Qian, Yingyiq3@pitt.eduYIQ3
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairLin, Yanyal14@pitt.eduYAL14
Committee MemberYouk, Adaayouk@pitt.eduAYOUK
Committee MemberTarhini, Ahmad Alitarhiniaa@upmc.eduAAT8
Date: 28 September 2015
Date Type: Publication
Defense Date: 6 July 2015
Approval Date: 28 September 2015
Submission Date: 3 June 2015
Access Restriction: 2 year -- Restrict access to University of Pittsburgh for a period of 2 years.
Number of Pages: 66
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Biostatistics
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: Melanoma
Date Deposited: 28 Sep 2015 18:39
Last Modified: 01 Sep 2017 05:15
URI: http://d-scholarship.pitt.edu/id/eprint/25338

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