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Maternal obesity, gestational weight gain, and child cognition, behavior, and academic achievement

Pugh, Sarah (2015) Maternal obesity, gestational weight gain, and child cognition, behavior, and academic achievement. Doctoral Dissertation, University of Pittsburgh. (Unpublished)

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Abstract

Attention-deficit hyperactivity disorder (ADHD) is the most prevalent developmental disability in the United States and can compromise a child’s behavioral and intellectual development. We used a longitudinal birth cohort from Pittsburgh, PA to study maternal pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) in relation to 1) offspring intelligence and executive function at age ten 2) offspring behavior and ADHD symptoms at age ten 3) offspring academic achievement at ages six, ten, and fourteen. Mother-child pairs (n=763) from the Maternal Health Practices and Child Development pregnancy cohort were followed from <21 weeks gestation to 14 years postpartum. Self-reported total GWG was classified using gestational-age standardized z-score charts and BMI was categorized in accordance with the World Health Organization (WHO) criteria. Validated assessment tools were used to measure child intelligence, executive function, and behaviors consistent with attention-deficit hyperactivity disorder (ADHD) as well as academic achievement. Compared with children of normal weight mothers, offspring of obese mothers had 3.2 lower IQ points (95% CI: -5.6, -0.8), were 12.7 seconds slower on the executive function scale (95% CI: 2.8, 22.7), and had increased problem behaviors consistent with ADHD including withdrawn or somatic complaints (adj β: 4.9 points, 95% CI: 1.7, 8.1), delinquent or aggressive behaviors (adj β: 4.2 points, 95% CI: 1.1, 7.3), and attention problems (adj β: 3.5 points, 95% CI: 1.2, 5.8) after adjusting for confounders. Academic achievement was also lower among children of obese mothers, compared with children of normal weight mothers. In generalized estimating equation models, high GWG was significantly associated with a 4 point decrease in reading (adjβ: -3.75, 95% CI: -7.1, -0.4) and spelling scores (adjβ: -3.90, 95% CI: -7.8, -0.2) at ages 6, 10, and 14. There was a non-significant trend towards lower offspring domain-specific cognition with high maternal GWG. This dissertation is important to public health because pre-pregnancy BMI and GWG are potentially modifiable factors and a reduction in obesity and excessive GWG could alleviate, although not eliminate, the burden of ADHD and related impairments in the population.


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Pugh, Sarahsap79@pitt.eduSAP79
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairBodnar, Lisabodnar@edc.pitt.eduLBODNAR
Committee MemberBrooks, Maria M.mbrooks@pitt.eduMBROOKS
Committee MemberHutcheon, Jenniferjhutcheon@cfri.ca
Committee MemberKatherine, Himeshimekp@upmc.edu
Committee MemberGale, Richardsongar@pitt.eduGAR
Date: 28 September 2015
Date Type: Publication
Defense Date: 11 June 2015
Approval Date: 28 September 2015
Submission Date: 29 June 2015
Access Restriction: 2 year -- Restrict access to University of Pittsburgh for a period of 2 years.
Number of Pages: 142
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Epidemiology
Degree: PhD - Doctor of Philosophy
Thesis Type: Doctoral Dissertation
Refereed: Yes
Uncontrolled Keywords: maternal, obesity, weight gain, child, cognition
Date Deposited: 28 Sep 2015 19:21
Last Modified: 01 Sep 2017 05:15
URI: http://d-scholarship.pitt.edu/id/eprint/25511

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