Implementing array comparative genomic hybridization in male infertility diagnostics

Beadling, Randall (2015) Implementing array comparative genomic hybridization in male infertility diagnostics. Master Essay, University of Pittsburgh.

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Abstract

Infertility is defined as the failure to conceive after twelve months of unprotected intercourse. It is a health burden with many psychological, economical, and social sequelae that can significantly decrease quality of life, and is often associated with serious medical disorders. Male infertility of genetic origin affects as many as 1 in 40 adult men, and can therefore be considered a common disease. Diagnosing male infertility can be a long and expensive process, involving several evaluations, tests for chemical exposures, endocrine panels, counseling, etc. Although up to half of male infertility may be of genic etiology, genetic testing is rarely performed. Of public health significance, Array Comparative Genomic Hybridization (aCGH) at the genomic level may be a viable tool for diagnosing male infertility of genic origin which affects up to 1 in 40 men, with clinical as well as economical utility. However, more research needs to be done in order to realize the full potential of aCGH for diagnosing male infertility. The Yatsenko lab of Magee-Womens Research institute and foundation is working to identify and characterize previously unknown candidate genes for male infertility and assess the usefulness of implementing aCGH as a standard of care test for diagnosing male infertility.

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Details

Item Type:	Other Thesis, Dissertation, or Long Paper (Master Essay)
Status:	Unpublished
Creators/Authors:	Creators Email Pitt Username ORCID Beadling, Randall rjb70@pitt.edu RJB70
Contributors:	Contribution Contributors Name Email Pitt Username ORCID Committee Chair Kammerer, Candace cmk3@pitt.edu CMK3 UNSPECIFIED Committee Member Yatsenko, Alex yatsenkoan@mwri.magee.edu ANY23 UNSPECIFIED
Date:	18 April 2015
Date Type:	Publication
Submission Date:	15 July 2015
Access Restriction:	No restriction; Release the ETD for access worldwide immediately.
Publisher:	University of Pittsburgh
Institution:	University of Pittsburgh
Schools and Programs:	School of Public Health > Human Genetics
Degree:	MPH - Master of Public Health
Thesis Type:	Master Essay
Refereed:	Yes
Uncontrolled Keywords:	male, infertility, array, comparative, genomic, hybridization, diagnostics, aCGH
Date Deposited:	19 Oct 2015 19:25
Last Modified:	02 Jul 2024 11:56
URI:	http://d-scholarship.pitt.edu/id/eprint/25629

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