Organozirconocene-mediated polyene synthesis: Preparation of asukamycin and manumycin a side chains

Wipf, P and Coish, PDG (1997) Organozirconocene-mediated polyene synthesis: Preparation of asukamycin and manumycin a side chains. Tetrahedron Letters, 38 (29). 5073 - 5076. ISSN 0040-4039

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Abstract

Hydrozirconation of a functionalized alkyne followed by transmetalation and 1,2-addition to α,β-unsaturated aldehydes was used for the syntheses of the eastern side chain of asukamycin and a precursor to the southern side chain common to asukamycin and manumycin A. These routes facilitate analog preparation, and the convergent zirconocene strategy represents an alternative to stepwise Wittig condensations or Stille couplings in polyene synthesis.

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Details

Item Type:	Article
Status:	Published
Creators/Authors:	Creators Email Pitt Username ORCID Wipf, P pwipf@pitt.edu PWIPF Coish, PDG
Date:	21 July 1997
Date Type:	Publication
Journal or Publication Title:	Tetrahedron Letters
Volume:	38
Number:	29
Page Range:	5073 - 5076
DOI or Unique Handle:	10.1016/s0040-4039(97)01129-5
Schools and Programs:	Dietrich School of Arts and Sciences > Chemistry
Refereed:	Yes
ISSN:	0040-4039
Date Deposited:	22 Jul 2015 13:15
Last Modified:	02 Feb 2019 15:56
URI:	http://d-scholarship.pitt.edu/id/eprint/25640

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