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The electron is a catalyst

Studer, A and Curran, DP (2014) The electron is a catalyst. Nature Chemistry, 6 (9). 765 - 773. ISSN 1755-4330

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The electron is an efficient catalyst for conducting various types of radical cascade reaction that proceed by way of radical and radical ion intermediates. But because electrons are omnipresent, catalysis by electrons often passes unnoticed. In this Review, a simple analogy between acid/base catalysis and redox catalysis is presented. Conceptually, the electron is a catalyst in much the same way that a proton is a catalyst. The 'electron is a catalyst' paradigm unifies mechanistically an assortment of synthetic transformations that otherwise have little or no apparent relationship. Diverse radical cascades, including unimolecular radical substitution reactions (S RN 1-type chemistry), base-promoted homolytic aromatic substitutions (BHAS), radical Heck-type reactions, radical cross-dehydrogenative couplings (CDC), direct arene trifluoromethylations and radical alkoxycarbonylations, can all be viewed as electron-catalysed reactions.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Studer, A
Curran, DPcurran@pitt.eduCURRAN
Date: 1 January 2014
Date Type: Publication
Journal or Publication Title: Nature Chemistry
Volume: 6
Number: 9
Page Range: 765 - 773
DOI or Unique Handle: 10.1038/nchem.2031
Schools and Programs: Dietrich School of Arts and Sciences > Chemistry
Refereed: Yes
ISSN: 1755-4330
MeSH Headings: Catalysis; Electrons; Free Radicals
PubMed ID: 25143210
Date Deposited: 17 Jul 2015 20:05
Last Modified: 02 Feb 2019 15:58


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