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ATM copy number loss as a biomarker for radioresistance in urothelial bladder cancer cell lines

Lawrence, Chad (2015) ATM copy number loss as a biomarker for radioresistance in urothelial bladder cancer cell lines. Master's Thesis, University of Pittsburgh. (Unpublished)

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Abstract

Cancer is one of the leading causes of death in the United States today. Various techniques have been adopted to combat this disease. These techniques include chemotherapy and ionizing radiation therapy. Previous studies have suggested that certain cancer cells are more likely to survive when exposed to ionizing radiation, a phenomenon known as radioresistance. In oral squamous cell carcinoma, one biomarker for radioresistance is the copy number loss of distal 11q (marked by the ATM gene) and defective TP53 function. Our study is designed to determine whether number loss of ATM is linked with radioresistance instead of the combination of distal 11q and defective TP53 function. Based on clonogenic data, we hypothesize that other factors including miR100 and/or SMARCA5 should be investigated as potential predictors of radioresistance.
Public Health Significance: Cancer is a widespread public health problem. The goal of this research is to identify targets that lead to increased therapeutic efficacy. In light of this new evidence, further studies can be designed to establish a more accurate biomarker for radioresistance in urothelial bladder cancer cell lines. Further studies should investigate the roles of miR100 and SMARCA5 in radioresistance in these cell lines. In essence, this research study shows that the ATM gene may not be the best predictor of radioresistance in bladder cancer cell lines, but perhaps a combination of events can explain our findings.


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Details

Item Type: University of Pittsburgh ETD
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Lawrence, Chadchl197@pitt.eduCHL197
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Thesis AdvisorGollin, Susanne
Committee MemberParikh, Rahul
Committee MemberBarmada, Michael
Date: 28 September 2015
Date Type: Publication
Defense Date: 15 July 2015
Approval Date: 28 September 2015
Submission Date: 17 July 2015
Access Restriction: 3 year -- Restrict access to University of Pittsburgh for a period of 3 years.
Number of Pages: 58
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Human Genetics
Degree: MS - Master of Science
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: Bladder Cancer ionizing radiation resistance atm ataxia telangectasia mutated biomarker
Date Deposited: 28 Sep 2015 18:31
Last Modified: 01 Sep 2018 05:15
URI: http://d-scholarship.pitt.edu/id/eprint/25666

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