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Sequence analysis of Raji Epstein-Barr virus DNA

Hatfull, G and Bankier, AT and Barrell, BG and Farrell, PJ (1988) Sequence analysis of Raji Epstein-Barr virus DNA. Virology, 164 (2). 334 - 340. ISSN 0042-6822

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The DNA sequence of the EcoRI Dhet and part of the BamHI E fragments of Raji EBV has been determined. Precise locations of two deletions in Raji DNA have been identified and their consequences for gene structure evaluated. The deletion in Raji of reading frames BALF1, BARF1, and BZLF2 and truncation of BALF2 and BERF5 probably account for the replication defect in this strain. The degree of sequence variation between B95-8 and Raji has been examined and shows considerable variation between genes. The latent membrane protein gene is exceptionally polymorphic and the initiator methionine for the late productive cycle protein overlapping the latent membrane protein is absent in Raji. © 1988.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Hatfull, Ggfh@pitt.eduGFH
Bankier, AT
Barrell, BG
Farrell, PJ
Date: 1 January 1988
Date Type: Publication
Journal or Publication Title: Virology
Volume: 164
Number: 2
Page Range: 334 - 340
DOI or Unique Handle: 10.1016/0042-6822(88)90546-6
Schools and Programs: Dietrich School of Arts and Sciences > Biological Sciences
Refereed: Yes
ISSN: 0042-6822
MeSH Headings: Amino Acid Sequence; Base Sequence; Chromosome Deletion; DNA, Viral--genetics; Genes, Viral; Genetic Variation; Herpesvirus 4, Human--genetics; Molecular Sequence Data; Mutation; Tumor Cells, Cultured; Virus Replication
PubMed ID: 2835854
Date Deposited: 30 Oct 2015 15:05
Last Modified: 02 Feb 2019 15:57


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