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Mycobacteriophages: Genes and genomes

Hatfull, GF (2010) Mycobacteriophages: Genes and genomes. Annual Review of Microbiology, 64. 331 - 356. ISSN 0066-4227

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Viruses are powerful tools for investigating and manipulating their hosts, but the enormous size and amazing genetic diversity of the bacteriophage population have emerged as something of a surprise. In light of the evident importance of mycobacteria to human health especially Mycobacterium tuberculosis, which causes tuberculosisâ€"and the difficulties that have plagued their genetic manipulation, mycobacteriophages are especially appealing subjects for discovery, genomic characterization, and manipulation. With more than 70 complete genome sequences available, the mycobacteriophages have provided a wealth of information on the diversity of phages that infect a common bacterial host, revealed the pervasively mosaic nature of phage genome architectures, and identified a huge number of genes of unknown function. Mycobacteriophages have provided key tools for tuberculosis genetics, and new methods for simple construction of mycobacteriophage recombinants will facilitate postgenomic explorations into mycobacteriophage biology. © 2010 by Annual Reviews. All rights reserved.


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Item Type: Article
Status: Published
CreatorsEmailPitt UsernameORCID
Hatfull, GFgfh@pitt.eduGFH
Date: 13 October 2010
Date Type: Publication
Journal or Publication Title: Annual Review of Microbiology
Volume: 64
Page Range: 331 - 356
DOI or Unique Handle: 10.1146/annurev.micro.112408.134233
Schools and Programs: Dietrich School of Arts and Sciences > Biological Sciences
Refereed: Yes
ISSN: 0066-4227
Article Type: Review
MeSH Headings: DNA, Viral--genetics; Gene Order; Genes, Viral; Genetic Variation; Genome, Viral; Mycobacteriophages--genetics; Mycobacterium--virology
PubMed ID: 20528690
Date Deposited: 26 Jan 2016 15:57
Last Modified: 02 Feb 2019 15:57


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