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Access to gastric tissue promotes the survival of axotomized neurons in the dorsal motor nucleus of the vagus in neonatal rats

Rinaman, L and Levitt, P (1991) Access to gastric tissue promotes the survival of axotomized neurons in the dorsal motor nucleus of the vagus in neonatal rats. Journal of Comparative Neurology, 313 (2). 213 - 226. ISSN 0021-9967

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Abstract

Lesioning the vagus nerve in the neck (cervical vagotomy) results in a rapid and virtually complete loss of motoneurons in the dorsal motor nucleus of the vagus in neonatal rats. The present study sought to determine whether access to gastric target tissue will promote the survival of these motoneurons after axotomy. Quantitative analysis demonstrate that subdiaphragmatic vagotomy, which leaves the cut vagal axons in close proximity to their normal gastric targets, results in significantly less motoneuron loss than cervical vagotomy. Furthermore, the loss of motoneurons after cervical vagotomy can be significantly reduced by transplanting embryonic gastric tissue to the neck of vagotomized neonatal host rats, in the vicinity of the cut axons. The survival effect of transplanted gastric tissue appears specific because control‐transplants of embryonic bladder tissue fail to reduce motoneuron death after cervical vagotomy. Injections of the neural tracers Fluoro‐Gold and cholera toxin‐horseradish peroxidase into gastric transplants labeled surviving motoneurons in cervically vagotomized rats, whereas tracer injections into bladder transplants or into host cervical tissues did not. These results indicate that neonatal vagal motoneurons are capable of making the adjustments necessary to survive axotomy if they have access to gastric target cells. The apparent dependence of injured neonatal vagal motoneurons on gastric tissue offers a new system in which to examine in vivo the trophic interactions between neurons and their targets. Copyright © 1991 Wiley‐Liss, Inc.

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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Rinaman, Lrinaman@pitt.eduRINAMAN
Levitt, P
Date: 1 January 1991
Date Type: Publication
Journal or Publication Title: Journal of Comparative Neurology
Volume: 313
Number: 2
Page Range: 213 - 226
DOI or Unique Handle: 10.1002/cne.903130203
Refereed: Yes
ISSN: 0021-9967
MeSH Headings: Animals; Animals, Newborn; Cell Communication; Cell Survival; Fetal Tissue Transplantation; Motor Neurons--physiology; Neck; Neurons, Afferent--physiology; Rats; Rats, Inbred Strains; Stomach--embryology; Stomach--physiology; Stomach--transplantation; Transplantation, Heterotopic; Urinary Bladder--transplantation; Vagotomy; Vagus Nerve--physiology; Vagus Nerve Injuries
PubMed ID: 1765581
Date Deposited: 25 Feb 2016 17:33
Last Modified: 02 Feb 2019 15:57
URI: http://d-scholarship.pitt.edu/id/eprint/26837

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