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Cholecystokinin induces Fos expression in catecholaminergic neurons of the macaque monkey caudal medulla

Schreihofer, DA and Cameron, JL and Verbalis, JG and Rinaman, L (1997) Cholecystokinin induces Fos expression in catecholaminergic neurons of the macaque monkey caudal medulla. Brain Research, 770 (1-2). 37 - 44. ISSN 0006-8993

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Abstract

Systemic administration of cholecystokinin octapeptide (CCK) slows gastric emptying, inhibits feeding, and stimulates pituitary hormone release in rats and primates. To characterize the central neural circuits that mediate these effects in primates, the present study analyzes the distribution and chemical phenotypes of caudal medullary neurons that are activated in rhesus and cynomolgus macaque monkeys after CCK treatment. Monkeys were injected intravenously with CCK (3 or 15 μg/kg b.wt) or vehicle solution (0.l5 M NaCl) then were anesthetized and perfused with fixative 75 min later. Coronal tissue sections through the caudal medulla were processed for immunocytochemical localization of the immediate-early gene product Fos as a marker of stimulus-induced neuronal activation, and were double-labeled for tyrosine hydroxylase to identify catecholaminergic cells. Many neurons in the area postrema, nucleus of the solitary tract, and ventrolateral medulla were activated to express Fos in monkeys after CCK treatment, similar to previous reports in rats. Treatment-activated neurons included substantial proportions of the A1/C1 and A2/C2 catecholaminergic cell groups, whereas neurons in the locus coeruleus (A6 cell group) were not activated. These results indicate that the autonomic, behavioral, and neuroendocrine effects produced by systemic administration of CCK involve hindbrain neural systems whose anatomical and chemical features are comparable in rats and primates.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Schreihofer, DA
Cameron, JLjcameron@pitt.eduJCAMERON
Verbalis, JG
Rinaman, Lrinaman@pitt.eduRINAMAN
Date: 3 October 1997
Date Type: Publication
Journal or Publication Title: Brain Research
Volume: 770
Number: 1-2
Page Range: 37 - 44
DOI or Unique Handle: 10.1016/s0006-8993(97)00732-4
Refereed: Yes
ISSN: 0006-8993
MeSH Headings: Animals; Catecholamines--physiology; Cholecystokinin--pharmacology; Cholinergic Fibers--drug effects; Cholinergic Fibers--metabolism; Female; Hypothalamus--physiology; Macaca fascicularis; Macaca mulatta; Male; Neurons--drug effects; Neurons--metabolism; Neurons--ultrastructure; Proto-Oncogene Proteins c-fos--biosynthesis; Solitary Nucleus--cytology; Solitary Nucleus--metabolism; Vagus Nerve--cytology; Vagus Nerve--metabolism
PubMed ID: 9372200
Date Deposited: 25 Feb 2016 17:37
Last Modified: 02 Feb 2019 15:57
URI: http://d-scholarship.pitt.edu/id/eprint/26845

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