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Nicotine enhances footshock- and lithium chloride-conditioned place avoidance in male rats

Buffalari, DM and Mollica, JK and Smith, TT and Schassburger, RL and Rinaman, L and Thiels, E and Donny, EC and Sved, AF (2016) Nicotine enhances footshock- and lithium chloride-conditioned place avoidance in male rats. Nicotine and Tobacco Research, 18 (9). 1920 - 1923. ISSN 1462-2203

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Abstract

© The Author 2016. Published by Oxford University Press on behalf of the Society for Research on Nicotine and Tobacco. All rights reserved. Introduction: Numerous studies have shown that nicotine (NIC) can enhance the reinforcing effects of non-NIC stimuli through a nonassociative mechanism. To date, it is unclear whether NIC reinforcement enhancement serves to increase behaviors motivated by rewarding stimuli only, or whether NIC potentiates behavior motivated by all stimuli, regardless of valence. Methods: The current study used a place conditioning procedure to examine whether acute NIC injection modulates avoidance of an environment previously associated with an aversive stimulus. Separate groups of rats underwent place conditioning using either lithium chloride (125 mg/kg/ml, i.p.) or footshock (0.75 mA) as the aversive stimulus. Other rats served as nonconditioned controls. The magnitude of place avoidance was assessed after acute NIC (0.1 or 0.4 mg/kg/ml, s.c.) or saline. Results: Rats avoided chambers previously paired with either lithium chloride or footshock, and conditioned place avoidance was significantly enhanced by NIC pre-treatment. Conclusions: These results demonstrate that the ability of NIC to enhance motivated behavior extends to behaviors elicited by aversive stimuli, evidence that NIC affects behavior motivated by a broader range of stimuli than previously appreciated. Implications: The current study examined whether the reinforcement enhancement properties of NIC apply to aversive stimuli by testing NIC enhancement of conditioned place avoidance in rats. The results demonstrate that NIC enhances the motivational impact of these distinct aversive stimuli, providing novel evidence that NIC affects behavior motivated by a broader range of stimuli than has previously been demonstrated.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Buffalari, DM
Mollica, JK
Smith, TTtgt4@pitt.eduTGT4
Schassburger, RL
Rinaman, Lrinaman@pitt.eduRINAMAN
Thiels, E
Donny, ECedonny@pitt.eduEDONNY
Sved, AFsved@pitt.eduSVED0000-0002-4631-7842
Date: 1 September 2016
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: Nicotine and Tobacco Research
Volume: 18
Number: 9
Page Range: 1920 - 1923
DOI or Unique Handle: 10.1093/ntr/ntw098
Institution: University of Pittsburgh
Refereed: Yes
ISSN: 1462-2203
Date Deposited: 18 Mar 2016 19:43
Last Modified: 02 Feb 2019 14:55
URI: http://d-scholarship.pitt.edu/id/eprint/26985

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