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The role of initial and longitudinal change in blood pressure on progression of arterial stiffness among multiethnic middle-aged men

Guo, J and Fujiyoshi, A and Masaki, K and Vishnu, A and Kadota, A and Barinas-Mitchell, EJM and Hisamatsu, T and Ahuja, V and Takashima, N and Evans, RW and Willcox, BJ and Miura, K and Rodriguez, B and Ueshima, H and Kuller, LH and Sekikawa, A (2017) The role of initial and longitudinal change in blood pressure on progression of arterial stiffness among multiethnic middle-aged men. Master Essay, University of Pittsburgh.

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Objective: A few studies have examined the longitudinal association of blood pressure (BP) with arterial stiffness progression, and the results were inconsistent. The objective of this study was to investigate the roles of initial BP and its longitudinal change on the progression of arterial stiffness measured using brachial-ankle pulse wave velocity (baPWV). Method: Study participants (n = 656) were from population-based samples of healthy men aged 40-49 years at baseline (213 White Americans, 47 AfricanAmericans, 152 Japanese Americans and 244 Japanese in Japan). BP measures, baPWV and other factors were examined at baseline and 4-7 years later. General linear regression was applied for statistical analyses. Result: Annual change in SBP (standardized coefficient: 0.33, P < 0.001), but not its baseline level (standardized coefficient: 0.03, P = 0.495), had a positive significant association with the progression of baPWV after adjusting for a wide range of standard cardiovascular risk factors. Similarly, annual changes in DBP (standardized coefficient: 0.35, P < 0.001), pulse pressure (standardized coefficient: 0.15, P = 0.001) and mean arterial pressure (standardized coefficient: 0.37, P < 0.001) were positively associated with the progression of baPWV. None of the baseline measures were related to the progression of baPWV. Conclusion: Our findings imply that, regardless of initial BP, effective monitoring and controlling of BP is important to slow down arterial wall stiffening and hence reduce cardiovascular risk.


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Item Type: Other Thesis, Dissertation, or Long Paper (Master Essay)
Status: Published
CreatorsEmailPitt UsernameORCID
Guo, Jjig38@pitt.eduJIG38
Fujiyoshi, A
Masaki, K
Vishnu, A
Kadota, A
Barinas-Mitchell, EJMbarinas@edc.pitt.eduEJB40000-0002-7280-7781
Hisamatsu, T
Ahuja, V
Takashima, N
Evans, RW
Willcox, BJ
Miura, K
Rodriguez, B
Ueshima, H
Kuller, LH
Sekikawa, Aakira@pitt.eduAKIRA
ContributionContributors NameEmailPitt UsernameORCID
Committee ChairSekikawa, Akiraakira@pitt.eduAKIRAUNSPECIFIED
Committee MemberMuldoon, Matthew Fmfm10@pitt.eduMFM10UNSPECIFIED
Date: 1 January 2017
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: Journal of Hypertension
Volume: 35
Number: 1
Page Range: 111 - 117
DOI or Unique Handle: 10.1097/hjh.0000000000001144
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Epidemiology
Thesis Type: Master Essay
Refereed: Yes
ISSN: 0263-6352
Date Deposited: 07 Sep 2016 17:58
Last Modified: 01 May 2021 05:15


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