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Clinical trial of high-dose green tea extract on hepatocellular injury in postmenopausal women in the United States

Yu, Zheming (2016) Clinical trial of high-dose green tea extract on hepatocellular injury in postmenopausal women in the United States. Master Essay, University of Pittsburgh.

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Abstract

Objective: To evaluate the liver toxicity effect of oral supplementation of a concentrated green tea extract (GTE) in postmenopausal women in the United States. Methods: In a clinical trial, 999 postmenopausal women were randomly assigned to either placebo arm or treatment arm receiving a daily dose of 1315 mg total tea catechins (including 843 mg epigallocatechin gallate) for 12 months. Baseline information on demographic characteristics, dietary intake and medication use were collected. Alanine transaminase (ALT) and aspartate transaminase (AST) as liver function tests were quantified in plasma collected from study participants at baseline, monthly for the first 6 months, and every 3 months for the last 6 months. A linear mixed-effect model was used to evaluate the effect of GTE intake on plasma ALT and AST levels, respectively. An unconditional logistic regression model was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) of developing abnormal liver function test (ALT > 60 U/L or AST >35 U/L) during the 12-month study period. Results: Overall, GTE supplements significantly increased ALT by 4.9 U/L (95% CI =3.8-6.0 U/L, P


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Details

Item Type: Other Thesis, Dissertation, or Long Paper (Master Essay)
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Yu, Zhemingzhy39@pitt.eduZHY39
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
Committee ChairYuan, Jian-Minyuanj@upmc.eduYUANJUNSPECIFIED
Committee MemberButler, Lesley M.butlerl3@pitt.eduBUTLERL3UNSPECIFIED
Committee MemberKensler, Thomas W.tkensler@pitt.eduTKENSLERUNSPECIFIED
Date: 28 April 2016
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Publisher: University of Pittsburgh
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Epidemiology
Degree: MPH - Master of Public Health
Thesis Type: Master Essay
Refereed: Yes
Date Deposited: 08 Sep 2016 14:33
Last Modified: 30 Oct 2018 12:56
URI: http://d-scholarship.pitt.edu/id/eprint/27423

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