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The effect of calcium addition on the dissolution of hydroxyapatite

Wang, Wenfu (2016) The effect of calcium addition on the dissolution of hydroxyapatite. Master's Thesis, University of Pittsburgh. (Unpublished)

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Hydroxyapatite (HA) has been widely used as a scaffold material for bone tissue engineering. It has an excellent biocompatibility but a low biodegradability. The calcium content in HA is thought to have an important effect on the degradation of the scaffold. The purpose of this thesis was to fabricate a highly porous HA foam using an emulsion direct foaming method by infiltration of calcium salt solution with different calcium concentration (2mol/L and 5mol/L) and sintering process. After that foam were immersed in Tris-bufffer Saline (TBS) at several different time points. We investigated the influence of infiltrated calcium salt in terms of their effects on weight loss/gain, surface morphology, and microstructural-level degradation with SEM observation and micro-CT. Interestingly there were a large amount of precipitation of calcium phases and detectable weight gain for the 2M samples. And for 5M samples, weight loss with time and a better dissolution behavior were observed.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Wang, Wenfuwew58@pitt.eduWEW58
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairNettleship, Ian
Committee MemberLee, Jung-Kun
Committee MemberChmielus, Markus
Date: 15 June 2016
Date Type: Publication
Defense Date: 31 March 2016
Approval Date: 15 June 2016
Submission Date: 30 March 2016
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 71
Institution: University of Pittsburgh
Schools and Programs: Swanson School of Engineering > Mechanical Engineering and Materials Science
Degree: MSMSE - Master of Science in Materials Science and Engineering
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: hydroxyapatite infiltration degradability dissolusion foam
Date Deposited: 15 Jun 2016 15:01
Last Modified: 15 Nov 2016 14:32


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