Wang, Wenfu
(2016)
The effect of calcium addition on the dissolution of hydroxyapatite.
Master's Thesis, University of Pittsburgh.
(Unpublished)
Abstract
Hydroxyapatite (HA) has been widely used as a scaffold material for bone tissue engineering. It has an excellent biocompatibility but a low biodegradability. The calcium content in HA is thought to have an important effect on the degradation of the scaffold. The purpose of this thesis was to fabricate a highly porous HA foam using an emulsion direct foaming method by infiltration of calcium salt solution with different calcium concentration (2mol/L and 5mol/L) and sintering process. After that foam were immersed in Tris-bufffer Saline (TBS) at several different time points. We investigated the influence of infiltrated calcium salt in terms of their effects on weight loss/gain, surface morphology, and microstructural-level degradation with SEM observation and micro-CT. Interestingly there were a large amount of precipitation of calcium phases and detectable weight gain for the 2M samples. And for 5M samples, weight loss with time and a better dissolution behavior were observed.
Share
| Citation/Export: |
|
| Social Networking: |
|
Details
| Item Type: |
University of Pittsburgh ETD
|
| Status: |
Unpublished |
| Creators/Authors: |
|
| ETD Committee: |
| Title | Member | Email Address | Pitt Username | ORCID |
|---|
| Committee Chair | Nettleship, Ian | | | | | Committee Member | Lee, Jung-Kun | | | | | Committee Member | Chmielus, Markus | | | |
|
| Date: |
15 June 2016 |
| Date Type: |
Publication |
| Defense Date: |
31 March 2016 |
| Approval Date: |
15 June 2016 |
| Submission Date: |
30 March 2016 |
| Access Restriction: |
No restriction; Release the ETD for access worldwide immediately. |
| Number of Pages: |
71 |
| Institution: |
University of Pittsburgh |
| Schools and Programs: |
Swanson School of Engineering > Mechanical Engineering and Materials Science |
| Degree: |
MSMSE - Master of Science in Materials Science and Engineering |
| Thesis Type: |
Master's Thesis |
| Refereed: |
Yes |
| Uncontrolled Keywords: |
hydroxyapatite infiltration degradability dissolusion foam |
| Date Deposited: |
15 Jun 2016 15:01 |
| Last Modified: |
15 Nov 2016 14:32 |
| URI: |
http://d-scholarship.pitt.edu/id/eprint/27453 |
Metrics
Monthly Views for the past 3 years
Plum Analytics
Actions (login required)
 |
View Item |
![[img]](https://d-scholarship.pitt.edu/style/images/fileicons/application_pdf.png)
![[feed]](/images/feed-icon-32x32.png){kind=icon}