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Homocysteine as a biomarker of subclinical cardiovascular disease in reproductive age women

Mereke, Alibek (2016) Homocysteine as a biomarker of subclinical cardiovascular disease in reproductive age women. Master Essay, University of Pittsburgh.

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Abstract

Public health relevance. Homocysteine (HCY) is an inflammatory marker that can potentially be used as a biomarker of subclinical cardiovascular disease (CVD) risk among women of reproductive age. The objective of this study was to determine if higher concentrations of HCY are associated with subclinical cardiovascular disease (CVD) (carotid intima-media thickness (IMT), pulse wave velocity (PWV) and blood pressure) among women 4 to 12 years after pregnancy. Our second aim was to determine if the concentrations of HCY differ between women with term and preterm births. Methods. This was a cross-sectional study of 100 women with a prior term (N=51) or preterm (N=49) births participating in The Women and Infant Study of Healthy Hearts (WISH study) who completed a structured interview and donated a sample of blood. Carotid artery intima-media thickness (IMT), carotid-femoral pulse wave velocity (PWV), blood pressure, HCY, and fasting lipids were measured 4 to 12 years after pregnancy. Linear regression models were used to assess whether HCY was associated with IMT, PWV, and blood pressure among reproductive age women. Univariate and multivariate analyses were used to evaluate a difference in mean concentrations of HCY between term and preterm groups. Results. In a simple linear regression model, HCY concentration was positively associated with IMT, and systolic and diastolic blood pressure (p-values


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Details

Item Type: Other Thesis, Dissertation, or Long Paper (Master Essay)
Status: Unpublished
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Mereke, Alibekalm312@pitt.eduALM312
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
Committee ChairLinkov, Faina Yfyl1@pitt.eduFYL1UNSPECIFIED
Committee MemberEvans, Rhobert W.rwe2@pitt.eduRWE2UNSPECIFIED
Committee MemberCatov, Janet M.jcatov@att.netUNSPECIFIEDUNSPECIFIED
Committee MemberRoberts, James M.robertsjm@mwri.magee.eduUNSPECIFIEDUNSPECIFIED
Date: 2016
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Publisher: University of Pittsburgh
Institution: University of Pittsburgh
Schools and Programs: Graduate School of Public Health > Epidemiology
Degree: MPH - Master of Public Health
Thesis Type: Master Essay
Refereed: Yes
Date Deposited: 09 Sep 2016 17:00
Last Modified: 02 May 2019 13:58
URI: http://d-scholarship.pitt.edu/id/eprint/27544

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