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Characterizing oropharyngeal swallowing following single lung transplantation in adults

Pomfret, Sarah A (2016) Characterizing oropharyngeal swallowing following single lung transplantation in adults. Undergraduate Thesis, University of Pittsburgh. (Unpublished)

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Swallowing is a physiologically complex kinematic process during which abnormal obstruction of bolus flow of incoordination can occur. Dysphagia, or a difficulty with swallowing, is a concern following single-lung transplantation (SLT) due to the high risk of recurrent laryngeal nerve damage, upper airway trauma secondary to orotracheal intubation, disruption of pulmonary sensorimotor circuits responsible for airway penetration, and the required levels of immunosuppression during and following surgery. Post-operatively, repetitive aspiration events are a major contributing factor in the long-term failure of lung allograft function. The goal of this descriptive, retrospective study is to quantitatively describe the characteristics of swallowing kinematic function through six durational measures in a group of 10 patients (age 49-68) following single-lung transplantation, describe airway protection ordinally through penetration-aspiration scale scores, and to compare findings from these patients to published norms for healthy adults. By explicitly describing the swallow physiology of a sample of patients with SLTs, clinically significant risk factors will be identified to help researchers and clinicians consider better treatment and safe swallowing strategies for future patients in order to mitigate adverse post-operative events, effectively increasing the functional lifespan of the transplant organ, and thusly decreasing morbidity and patient mortality.


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Pomfret, Sarah ASAP87@pitt.eduSAP87
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Thesis AdvisorCoyle, James Ljcoyle@pitt.eduJCOYLE
Committee MemberMartino,
Committee MemberMormer, Elaineemormer@pitt.eduEMORMER
Committee MemberShaiman, Susanshaiman@pitt.eduSHAIMAN
Date: 25 April 2016
Date Type: Publication
Defense Date: 24 March 2016
Approval Date: 25 April 2016
Submission Date: 19 April 2016
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Number of Pages: 49
Institution: University of Pittsburgh
Schools and Programs: David C. Frederick Honors College
School of Health and Rehabilitation Sciences > Communication Science and Disorders
Degree: BPhil - Bachelor of Philosophy
Thesis Type: Undergraduate Thesis
Refereed: Yes
Uncontrolled Keywords: Swallowing, oropharyngeal, dysphagia, aspiration, adults, lung transplantation, videofluoroscopy
Date Deposited: 25 Apr 2016 19:29
Last Modified: 15 Nov 2016 14:32


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