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Comparing the immunogenicity of influenza vaccines LAIV and IIV in pediatric patients during the 2014-2015 season

Archibald, Crystal (2016) Comparing the immunogenicity of influenza vaccines LAIV and IIV in pediatric patients during the 2014-2015 season. Master's Thesis, University of Pittsburgh. (Unpublished)

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Influenza virus causes a contagious respiratory illness in humans that poses a major public health threat, especially to vulnerable populations such as children and adolescents, who have less mature immune systems. Influenza infections are responsible for over 200,000 hospitalizations and over 3,600 deaths a year. The influenza vaccine is the best form of prevention from influenza illness due to the vaccines ability to elicit an antibody response without causing illness. Currently, there are two types of influenza vaccines available to children and adolescents, the inactivated influenza vaccine (IIV) and the live attenuated influenza vaccine (LAIV). The present study was designed to compare the immunogenicity of the two vaccines in pediatric participant’s ages 3 to 17 years. We hypothesized that the LAIV vaccine would produce an increased breath and enhanced antibody response to influenza vaccination compared to the IIV vaccine. Results from this study suggest that IIV was superior compared to LAIV at eliciting immune responses following vaccination. However, potential limitations include the fact that current assays measure immune responses in peripheral blood only and may not reflect mucosal immunity. Further, due to issues with the H1N1 virus strain in the LAIV vaccine, these results need to be confirmed in a season where LAIV vaccine is immunogenic (2015-16).


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Item Type: University of Pittsburgh ETD
Status: Unpublished
CreatorsEmailPitt UsernameORCID
Archibald, Crystalcas0586@hotmail.comCRS117
ETD Committee:
TitleMemberEmail AddressPitt UsernameORCID
Committee ChairCole, Kelly Stefanostefcole@pitt.eduSTEFCOLE
Committee MemberBarratt-Boyes, Simon Msmbb@pitt.eduSMBB
Committee MemberAyyavoo, Velpandivelpandi@pitt.eduVELPANDI
Date: 29 June 2016
Date Type: Publication
Defense Date: 8 January 2016
Approval Date: 29 June 2016
Submission Date: 28 April 2016
Access Restriction: 3 year -- Restrict access to University of Pittsburgh for a period of 3 years.
Number of Pages: 59
Institution: University of Pittsburgh
Schools and Programs: School of Public Health > Infectious Diseases and Microbiology
Degree: MPH - Master of Public Health
Thesis Type: Master's Thesis
Refereed: Yes
Uncontrolled Keywords: Influenza Vaccine
Date Deposited: 29 Jun 2016 19:36
Last Modified: 01 May 2019 05:15


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