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Impact of the sensory neurons on melanoma growth in vivo

Keskinov, AA and Tapias, V and Watkins, SC and Ma, Y and Shurin, MR and Shurin, GV (2016) Impact of the sensory neurons on melanoma growth in vivo. PLoS ONE, 11 (5).

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Abstract

© 2016 Keskinov et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Nerve endings are often identified within solid tumors, but their impact on the tumor growth and progression remains poorly understood. Emerging data suggests that the central nervous system may affect cancer development and spreading via the hypothalamic-pituitary-adrenal axis and autonomous nervous system. However, the role of the afferent sensory neurons in tumor growth is unclear, except some reports on perineural invasion in prostate and pancreatic cancer and cancer-related pain syndrome. Here, we provide the results of primary testing of the concept that the interaction between melanoma cells and sensory neurons may induce the formation of tumor-supporting microenvironment via attraction of immune regulatory cells by the tumor-activated dorsal root ganglion (DRG) neurons. We report that despite DRG cells not directly up-regulating proliferation of melanoma cells in vitro, presence of DRG neurons allows tumors to grow significantly faster in vivo. This effect has been associated with increased production of chemokines by tumor-activated DRG neurons and attraction of myeloid-derived suppressor cells both in vitro and in vivo. These initial proof-of-concept results justify further investigations of the sensory (afferent) nervous system in the context of tumorigenesis and the local protumorigenic immunoenvironment.


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Details

Item Type: Article
Status: Published
Creators/Authors:
CreatorsEmailPitt UsernameORCID
Keskinov, AAank142@pitt.eduANK142
Tapias, V
Watkins, SCsimon.watkins@pitt.eduSWATKINS
Ma, Y
Shurin, MRmshurin@pitt.eduMSHURIN
Shurin, GVgshurin@pitt.eduGSHURIN
Contributors:
ContributionContributors NameEmailPitt UsernameORCID
EditorChen, SuzieUNSPECIFIEDUNSPECIFIEDUNSPECIFIED
Date: 1 May 2016
Date Type: Publication
Access Restriction: No restriction; Release the ETD for access worldwide immediately.
Journal or Publication Title: PLoS ONE
Volume: 11
Number: 5
DOI or Unique Handle: 10.1371/journal.pone.0156095
Institution: University of Pittsburgh
Schools and Programs: School of Medicine > Cell Biology and Molecular Physiology
School of Medicine > Immunology
School of Medicine > Pathology
Refereed: Yes
Date Deposited: 22 Dec 2016 16:02
Last Modified: 13 Nov 2018 05:55
URI: http://d-scholarship.pitt.edu/id/eprint/28228

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